Results 191 to 200 of about 67,341 (246)

GatorST: A Versatile Contrastive Meta‐Learning Framework for Spatial Transcriptomic Data Analysis

open access: yesSmall Methods, EarlyView.
GatorST learns spatially informed embeddings for spatial transcriptomics by coupling two‐hop subgraph graph convolutions with cluster‐aware pseudo‐label supervision and episodic contrastive meta‐learning. The framework captures neighbor‐level topology and tissue‐wide expression semantics without heavy augmentations, delivering robust representations ...
Zhenhao Zhang   +5 more
wiley   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

open access: yesVIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai   +11 more
wiley   +1 more source

Quantitative micro‐XRF combined with X‐ray imaging reveals correlations between Zn concentration and dentin tubule porosity across entire teeth

open access: yesVIEW, EarlyView.
The combination of calibrated micro‐CT and quantitative micro‐XRF measurement facilitates the correlation of density and composition in the 3D macro‐structure of teeth. Zn concentration in dentin increases by a factor of 10 toward the pulp. Incidentally, the overall density decreases, showing an association between Zn and the dentin tissue porosity ...
Ioanna Mantouvalou   +11 more
wiley   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

open access: yesVIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li   +5 more
wiley   +1 more source

Short‐Term Multi‐Horizon Line Loss Rate Forecasting of a Distribution Network Using Attention‐GCN‐LSTM

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Accurately predicting line loss rates is crucial for effective management in distribution networks, particularly for short‐term multihorizon forecasts ranging from 1 hour to 1 week. In this study, we propose attention‐GCN–LSTM, a novel method that integrates graph convolutional networks (GCN), long short‐term memory (LSTM) and a three‐level ...
Jie Liu   +4 more
wiley   +1 more source

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