Results 61 to 70 of about 4,364,411 (360)
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Emergent memory from tapping collisions in active granular matter
Communications PhysicsIn an equilibrium thermal environment, random elastic collisions between background particles and a tracer establish the picture of Brownian motion fulfilling the celebrated Einstein relation between diffusivity and mobility.
Lorenzo Caprini +6 more
doaj +1 more source
EPJ Web of Conferences, 2017 We develop a method to investigate the microscopic origin of granular fluidity. We design a Couette cell in which we can probe the flow of soft hydrogel suspensions.
Workamp Marcel +2 more
doaj +1 more source
Cooperation in a fluid swarm of fuel-free micro-swimmers
Nature Communications, 2022 The authors introduce a light powered artificial micro-swimmers performing biological-like dynamics relevant for swarm robotics. The experimental dense swarms are shown to form artificial active clusters with internal fluid-like and turbulent dynamics ...
Matan Yah Ben Zion +3 more
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
New insight into cataract formation -- enhanced stability through mutual attraction [PDF]
, 2007 Small-angle neutron scattering experiments and molecular dynamics simulations combined with an application of concepts from soft matter physics to complex protein mixtures provide new insight into the stability of eye lens protein mixtures.
A. Stradner +12 more
core +2 more sources
Ferroelectric Nematic Liquid Crystals Showing High Birefringence
Advanced ScienceHigh birefringence nematic liquid crystals are particularly demanded for adaptive optics applications in the infrared spectrum because it enable a thinner cell gap for achieving fast response time and improved diffraction efficiency.
Yaohao Song +5 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Transparent gel engineering materials for 3D gel printing
Nihon Kikai Gakkai ronbunshu, 2017 Recently our group developed 3D gel printer named “SWIM-ER” (soft and wet industrial material - easy realizer). Here we aim to improve the gel materials used for SWIM-ER system about the problems around free-shaping, transparency, and mechanical strength.
Taishi TASE +6 more
doaj +1 more source