Results 71 to 80 of about 4,364,411 (360)

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Prospects for the direct detection of neutralino dark matter in orbifold scenarios [PDF]

, 2007
We analyse the phenomenology of orbifold scenarios from the heterotic superstring, and the resulting theoretical predictions for the direct detection of neutralino dark matter. In particular, we study the parameter space of these constructions, computing
A. Brignole, A. Ibarra, Carlos Muñoz, CDF collaboration, CDF collaboration, D.G. Cerdeño, D.G. Cerdeño, DAMA collaboration, David G Cerdeño, H. Nakano, Heavy Flavor Averaging Group (HFAG) collaboration, Heavy Flavor Averaging Group (HFAG) collaboration, J. Amaré ., J. Bijnens, J.E. Kim, J.E. Kim, K. Adel, M. Kawasaki, M. Misiak ., P. Ullio, S. Baek, S. Baek, See in: T. Kinoshita, Tatsuo Kobayashi, V. Barger, XENON collaboration   +25 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

James Fergason, a Pioneer in Advancing of Liquid Crystal Technology [PDF]

, 2013
James Lee Fergason (1934 - 2008) focused his research on the liquid crystals. His studies correspond to a relevant part of the history of soft matter science and technology of liquid crystals.
Sparavigna, Amelia Carolina
core   +1 more source

The EDGES 21 cm Anomaly and Properties of Dark Matter

, 2018
The recently claimed anomaly in the measurement of the 21 cm hydrogen absorption signal by EDGES at $z\sim 17$, if cosmological, requires the existence of new physics.
Fraser, Sean, Hektor, Andi, Hütsi, Gert, Kannike, Kristjan, Marzo, Carlo, Marzola, Luca, Racioppi, Antonio, Raidal, Martti, Spethmann, Christian, Vaskonen, Ville, Veermäe, Hardi   +10 more
core   +1 more source

Non-equilibrium umbrella sampling applied to force spectroscopy of soft matter [PDF]

, 2015
Physical systems often respond on a timescale which is longer than that of the measurement. This is particularly true in soft matter where direct experimental measurement, for example in force spectroscopy, drives the soft system out of equilibrium and ...
Evans, Denis J., Gao, Y. X., Sevick, E. M., Wang, G. M., Williams, D. R. M., Williams, Stephen R.   +5 more
core   +1 more source

Emergence of anomalous dynamics in soft matter probed at the European XFEL

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The European XFEL is a hard X-ray Free-Electron Laser (FEL) with pulse repetition rates in the megahertz regime. Thus, sample dynamics in the microsecond and submicrosecond regime can be accessed by means of X-ray photon correlation ...
F. Lehmkühler, F. Dallari, Avni Jain, M. Sikorski, J. Möller, L. Frenzel, I. Lokteva, G. Mills, M. Walther, H. Sinn, F. Schulz, M. Dartsch, V. Markmann, R. Bean, Yoonhee Kim, P. Vagovič, A. Madsen, A. Mancuso, G. Grübel   +18 more
semanticscholar   +1 more source

Soft matter in the loop

Nature Physics, 2023
Currently, a general framework explaining the fundamental dynamic transitions from solid to fluid of mechanically probed soft materials is lacking. Now, a unifying van der Waals-like model is proposed that describes the dynamic solid–liquid transition in the rheology of these materials.
Nick Oikonomeas-Koppasis, Peter Schall
openaire   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Sequential self-assembly of DNA functionalized droplets

Nature Communications, 2017
Natural complex systems are often constructed by sequential assembly but this is not readily available for synthetic systems. Here, the authors program the sequential self-assembly of DNA functionalized emulsions by altering the DNA grafted strands.
Yin Zhang, Angus McMullen, Lea-Laetitia Pontani, Xiaojin He, Ruojie Sha, Nadrian C. Seeman, Jasna Brujic, Paul M. Chaikin   +7 more
doaj   +1 more source