Results 221 to 230 of about 635,186 (354)

Submucosal laryngeal lesions: A puzzling diagnostic conundrum. [PDF]

Eur J Radiol Open
Lee MS, Lee J, Wiggins R.
europepmc   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

Advanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou, Peilong Lai, Guanjie Peng, Bo Lu, Lizhen Jiang, Xinyue Li, Jinghong Chen, Ladi Mo, Qiong Mao, Haichuan Zhang, Jinxin Fang, Yi Meng, Aochu Liu, Yingyin Gao, Andong Huang, Wenhui Lin, Shiwen Hu, Zerong Guan, Xiaolan Ye, Zhenguo Liu, Liling Jiang, Yueyuan Zheng, Xianping Shi   +22 more
wiley   +1 more source

Extra-axial chordoma in the distal fibula and the importance of ankle reconstruction. [PDF]

World J Surg Oncol
Casas Gállego VR, Perez Muñoz I, Sanz Pascual MDC, Gonzalez Lizan F, Reguero Callejas ME, Delgado Martínez I.   +5 more
europepmc   +1 more source

Intra- and inter-observer agreement in histological assessment of canine soft tissue sarcoma [PDF]

, 2017
Antonescu, Banks, Bobstock, Chase, Choong, Coindre, Coindre, Dennis, Ettinger, Ettinger, Federer, Guillou, Harris, Irshad, Kuntz, McChesney, McSporran, Meuten, Sargan, Stefanello, Theilen, Tomita   +21 more
core   +2 more sources

DSG2+ Cancer Stem Cells Co‐Located With FAP+ Myofibroblasts in the Tumor Boundary That Determines the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Cancer stem cells (CSCs) in non‐small cell lung cancer display pronounced plasticity and spatial heterogeneity. By integrating single‐cell and spatial transcriptomics, this study defines a DSG2‐associated CSC program and reveals a tumor‐margin niche formed with FAP+ myofibroblasts.
Guangyu Fan, Le Tang, Tongji Xie, Mengwei Yang, Lin Li, Sheng Yang, Puyuan Xing, Xiaohong Han, Yuankai Shi   +8 more
wiley   +1 more source

Encapsulated Enigma: Surgical Resolution of a Lingual Lipoma Affecting Oral Functions. [PDF]

Clin Case Rep
Delia G, Battaglia F, Lentini M, Franchina M, Pepe L, Stagno d'Alcontres F.   +5 more
europepmc   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Retroperitoneal malignant peripheral nerve sheath tumor in a patient with neurofibromatosis type 1: a case report. [PDF]

BMC Surg
Qian L, Ye X, Sun J.
europepmc   +1 more source

Seminal Vesicle Soft Tissue Neoplasm [PDF]

, 2020
openaire   +1 more source