Results 131 to 140 of about 2,534,544 (260)

Broader Familial Cancer Risk in Relatives of Testicular Cancer Patients: Insights From Two Mediterranean Populations

Andrology, EarlyView.
ABSTRACT Background Familial clustering of testicular germ cell tumour (TGCT) is well‐established, whereas the risk of non‐testicular cancer among relatives remains inconsistent across studies. Objective To evaluate the overall and site‐specific cancer risk among first‐degree relatives and grandparents of TGCT patients compared to cancer‐free controls.
Csilla Krausz, Chiara Abrardo, Viktoria Rosta, Daniel Moreno‐Mendoza, Luca Bressan, Matteo Vannucci, Rebecca Passerotti, Arianna Meacci, Ginevra Farnetani, Viola Bonini, Giovanni Corona, Maria Grazia Fino, Eduard Ruiz‐Castañé, Antoni Riera‐Escamilla   +13 more
wiley   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Depth and Procedure Specific Effects of Antimicrobial Versus Conventional Sutures on Surgical Site Infection: A Systematic Review and Meta‐Analysis

ANZ Journal of Surgery, EarlyView.
Antimicrobial sutures may be particularly beneficial in colorectal and abdominal procedures, where reductions in deep SSI may offset the additional suture cost. Several studies also reported favorable wound‐healing outcomes. ABSTRACT Background Surgical site infections (SSIs) are common postoperative complications that delay wound healing and increase ...
Ryan Muakkassa, Andrew Roach, Ahmed Adham R. Elsayed, Marc D. Basson   +3 more
wiley   +1 more source

Factors Affecting Surgical Outcomes Following Rotationplasty in Paediatric Sarcoma: A Literature Review

ANZ Journal of Surgery, EarlyView.
Rotationplasty is a durable limb‐salvage option for paediatric lower‐limb sarcoma. Across 58 studies and 1,217 patients, long‐term functional, psychosocial, and quality‐of‐life outcomes were favourable, often surpassing amputation and endoprosthetic reconstruction.
Rachel H. Ko, Stewart Morrison, Daniel J. Wilks   +2 more
wiley   +1 more source

Soft Tissue Sarcoma in Contact with Bone: Is Bone Resection Indicated?

Treating soft tissue sarcoma of the extremities requires a multidisciplinary team in a referral sarcoma center. Combining chemotherapy, radiotherapy, and surgery is crucial in high-grade, deep, and large soft tissue tumors.
Pala, E., Cerchiaro, Maria chiara, Trovarelli, G., Ruggieri, P.   +3 more
core   +1 more source

Dermal chondrosarcoma in a cat with prolonged survival after limb amputation

Australian Veterinary Journal, EarlyView.
A 5‐year‐old male entire domestic shorthair cat presented with a firm dermal mass on the dorsal left metatarsal region. Diagnostic investigations included haematology, biochemistry, urinalysis, biopsy, histopathology and computed tomography staging. Histopathology of the tissue biopsy, including immunohistochemistry, confirmed a dermal chondrosarcoma ...
A Ivanovs, DR Killick, I Amores‐Fuster, J Barton, W Humphreys, R Blundell   +5 more
wiley   +1 more source

Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiomyosarcoma [Corrigendum]

, 2016
Dr De Sanctis, Efficacy of trabectedin in advanced soft tissue sarcoma: beyond lipo- and leiDe Sanctis R, Marrari A, Marchetti S, et al. Drug Des Devel Ther.
Quagliuolo V, De Sanctis R, Mussi C, Marrari A, Bastoni S, Daolio P, Balzarini L, Santoro A, Lutman FR, Bertuzzi AF, Marchetti S   +10 more
core  

Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma

Soft tissue sarcoma is a broad family of mesenchymal malignancies exhibiting remarkable histological diversity. We portray the proteomic landscape of 272 soft tissue sarcomas representing 12 major subtypes.
Yufeng Liu, Yexin Tong, Chen Ding, Shaoshuai Tang, Hang Xiang, Rundong Fang, Subei Tan, Peng Ran, Jie Huang, Zhenmei Yao, Yuqin Ding, Xuetong Yue, Yingyong Hou, Zixiang Yu, Wen Huang, Qiao Zhang, Weiqi Lu, Jiacheng Lv, Yunzhi Wang, Chen Xu, Yuhong Zhou, Mingjun Sun, Ning Xu, Rongkui Luo, Ziyan Xu, Sujie Akesu   +25 more
core   +1 more source

Complement receptor C3aR marks heterogeneous tumor‐associated macrophage states associated with improved survival in IDH‐wildtype glioblastoma

Brain Pathology, EarlyView.
C3aR expression in IDH‐wildtype glioblastoma is predominantly associated with the myeloid/macrophage compartment and heterogeneous macrophage states. C3aR‐high tumors are enriched among MGMT promoter‐methylated tumors and show improved overall survival, although the prognostic association requires independent validation.
Marion Imara, Yosra Bedoui, Théotime Pignolet, Sebastien Freppel, Camille Brochard, Auguste Delattre, David Cappellen, Luc Bauchet, Mohamed Khettab, Franck Ah‐Pine   +9 more
wiley   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source