Results 161 to 170 of about 173,430 (355)

A YAP/TAZ–CDC6 Axis Initiates and Maintains Malignant Transformation

Cancer Science, EarlyView.
This study demonstrates that constitutive activation of YAP or TAZ is sufficient to induce and maintain malignant transformation in fibroblasts, identifying them as essential oncogenic drivers. Transcriptomic and functional analyses revealed CDC6 as a critical downstream effector of YAP/TAZ, with elevated expression linked to tumorigenesis across ...
David Nduru, Yudai Ohta, Akihiro Nita, Mayumi Niimura, Samson Ngurari, Toshiro Moroishi   +5 more
wiley   +1 more source

Paediatric soft tissue sarcomas in a resource constrain setting: Grade and stage at presentation and at oncologic intervention are usually of poor prognostic characteristics. [PDF]

, 2020
Gabriel Olabiyi Ogun, Uchenna O Ezenkwa, Taiwo Olabimpe Babatunde, Michael Nweke, Omolade O. Adegoke, Oludare O. Olulana, Biobele J. Brown   +6 more
openalex   +1 more source

Genotype–Phenotype Correlations of Li–Fraumeni Syndrome in Japan Children's Cancer Group LFS20 Study Cohort

Cancer Science, EarlyView.
This study investigates genotype–phenotype correlations in Japanese families with germline TP53 pathogenic variants, collected through a nationwide prospective cancer surveillance study (JCCG LFS‐20). Among 41 families analyzed, 36 met criteria for Li–Fraumeni syndrome (LFS), and 5 were classified as attenuated LFS.
Fumito Yamazaki, Yoshiko Nakano, Masashi Sanada, Hiroki Kurahashi, Shunsuke Miyai, Arisa Ueki, Yuko Watanabe, Daisuke Hasegawa, Shuhei Karakawa, Toshifumi Ozaki, Akira Hirasawa, Akiko M. Saito, Eisuke Inoue, Motohiro Kato, Hiroyoshi Hattori   +14 more
wiley   +1 more source

Evaluating referral patterns and treatment timeliness for soft tissue sarcoma in rural WA : insights from the WA state sarcoma service [PDF]

Ellen Maclean, Vindya Johnston, Chloe Price, Andrew Coveney, Rupert Hodder   +4 more
openalex   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

The greatest achievements in oncology in 2022 – melanoma and skin carcinomas

Archives of Medical Science, 2022
Piotr Rutkowski
doaj   +1 more source

Atypical Fibroxanthoma/Pleomorphic Dermal Sarcoma With Osseous Metaplasia: A Series of Three Cases

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare mesenchymal tumors typically arising on sun‐damaged skin of the head and neck in elderly patients. PDS is a more aggressive tumor but with similar demographics, cellular morphology, immunohistochemical features, and genetic findings.
Taylor Novice, Yitong Xu, Thomas Brenn, Scott C. Bresler   +3 more
wiley   +1 more source

Alveolar soft part sarcoma in children and adolescents: A report from the Soft-Tissue Sarcoma Italian Cooperative Group

, 2000
Michela Casanova, Andrea Ferrari, Gianni Bisogno, Giovanni Cecchetto, Eleonora Basso, Bruno De Bernardi, Paolo Indolfi, F. Fossati Bellani, Modesto Carli   +8 more
openalex   +1 more source

Defensive medicine in dermatological practice – Dermatopathology as a mirror of structural challenges

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Defensive medicine refers to diagnostic or therapeutic actions taken primarily to reduce legal liability rather than to benefit the patient. In dermatopathology, defensive practices manifest in frequent immunohistochemical testing, overly cautious report phrasing, and reliance on multidisciplinary tumor boards.
Cornelia Sigrid Lissi Müller, Torsten Hansen, Claus Renzelmann   +2 more
wiley   +1 more source

Intra- and inter-observer agreement in histological assessment of canine soft tissue sarcoma [PDF]

, 2017
Antonescu, Banks, Bobstock, Chase, Choong, Coindre, Coindre, Dennis, Ettinger, Ettinger, Federer, Guillou, Harris, Irshad, Kuntz, McChesney, McSporran, Meuten, Sargan, Stefanello, Theilen, Tomita   +21 more
core   +2 more sources