Results 241 to 250 of about 121,021 (313)

Normal tissue outlining guidelines development for soft tissue sarcoma of the extremities. [PDF]

Clin Transl Radiat Oncol
Simões R, Gulliford S, Shah P, McAtavey E, Richardson E, Chowdhury U, Fray L, Butt R, Augustin Y, Sarang R, Kilinc R, Iqbal M, Moulay-Dehbi H, Miles E, Hoskin P, Zaidi S, Harrington KJ, Miah AB.   +17 more
europepmc   +1 more source

A YAP/TAZ–CDC6 Axis Initiates and Maintains Malignant Transformation

Cancer Science, Volume 117, Issue 2, Page 353-363, February 2026.
This study demonstrates that constitutive activation of YAP or TAZ is sufficient to induce and maintain malignant transformation in fibroblasts, identifying them as essential oncogenic drivers. Transcriptomic and functional analyses revealed CDC6 as a critical downstream effector of YAP/TAZ, with elevated expression linked to tumorigenesis across ...
David Nduru, Yudai Ohta, Akihiro Nita, Mayumi Niimura, Samson Ngurari, Toshiro Moroishi   +5 more
wiley   +1 more source

Feasibility and Tolerability of Arterial Infusion Chemotherapy and Embolization for Recurrent/Metastatic Soft Tissue Sarcoma: A Retrospective Exploratory Study. [PDF]

Drug Des Devel Ther
Li J, Liu R, Zhu BR, Wang DL, Zhou JM, Yang WW, Wang MQ.   +6 more
europepmc   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, Volume 59, Issue 2, February 2026.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

First-line Anlotinib plus Anthracyclines and Ifosfamide Followed by Anlotinib Maintenance in Advanced Soft-Tissue Sarcoma: A Phase II Single-Arm Trial. [PDF]

Clin Cancer Res
Zhao JK, Liu ZJ, Wang R, Fu H, Liu MY, Xu J, Xu X, Fan XC, Hu WY, Zhang H, Xu N, Hao T, Yuan HT, Zhang JB, Li MH, Zhou L, Yang CS, Wang XY, Zhu DY.   +18 more
europepmc   +1 more source

WHO classification of skin tumours: key updates in the fifth edition

Histopathology, Volume 88, Issue 3, Page 555-568, February 2026.
This review article summarizes the key updates in the 5th edition of the WHO Classification of Skin Tumours. It provides an overview of the major changes and new entities specific to the skin section, covering areas such as epidermal, melanocytic, mesenchymal and other tumours. The 5th edition of the World Health Organization Classification of Tumours (
Gabrielle Goldman‐Lévy, Raymond Barnhill, Boris C. Bastian, Werner Kempf, David Elder, Pedram Gerami, Wayne Grayson, Dmitry Kazakov, Daniela Massi, Jane Messina, Arnaud de la Fouchardière, Alexander J. Lazar, Thomas Brenn, Brian Rous, Andrew Field, Anthony Gill, Jennelle C. Hodge, Joseph D Khoury, Katia Leite, Shahin Sayed, Puay Hoon Tan, Rosalie Elenitsas, Eduardo Calonje, Lyn M. Duncan, Liang Zhiyong, Holger Moch, Rajendra Singh, Harshima Wijesinghe, Ian Cree, Dilani Lokuhetty   +29 more
wiley   +1 more source

Multimodal prediction of metastatic relapse using federated deep learning in soft-tissue sarcoma with a complex genomic profile. [PDF]

Sci Rep
Maussion C, Coindre JM, Blay JY, Schutte K, Camara A, Loarer FL, Perret R, Jean-Denis M, Meurgey A, Ducimetiere F, Giraud A, Courrèges JB, Meeus P, Michot A, Bendjebbar E, Ogier du Terrail J, Italiano A, Karanian M.   +17 more
europepmc   +1 more source

GPNMB immunohistochemistry is a useful ancillary tool for the diagnosis of pulmonary lymphangioleiomyomatosis

Histopathology, Volume 88, Issue 3, Page 698-709, February 2026.
We evaluated the diagnostic utility of GPNMB immunohistochemistry in LAM. GPNMB showed strong expression in LAM cells, while the differential diagnostic mimics showed no or only low expression. Based on its 100% sensitivity and specificity in our cohort, GPNMB is a highly reliable immunohistochemical marker for the diagnosis of LAM.
Fatime Szalai, Judit Pápay, Katalin Dezső, Levente Kuthi, Anna Sebestyén, András Khoór, Ildikó Krencz   +6 more
wiley   +1 more source

Potential Mechanisms for Immunotherapy Resistance in Adult Soft-Tissue Sarcoma. [PDF]

Target Oncol
Kret ZS, Sweder RJ, Pollock R, Tinoco G.
europepmc   +1 more source