Results 171 to 180 of about 31,731 (259)

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

A Clinically Compatible Method for Generating Preoperative Finite Element Models to Simulate Facial Appearance and Movements in Orthognathic Surgery. [PDF]

Int J Numer Method Biomed Eng
Picard MC, Nazari MA, Perrier P, Bettega G, Lartizien R, Rochette M, Payan Y.   +6 more
europepmc   +1 more source

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

Graph transformer Q-network for collaborative governance and decentralized decision-making in multi-intersection networks. [PDF]

Sci Rep
Zhang H.
europepmc   +1 more source

Graphene Aerogels With Spherical Pore Structure for Broad Frequency Regulation and Enhanced Low‐Frequency Response

Advanced Science, EarlyView.
A graphene aerogel with a spherical‐pore structure is constructed via microbubble templating. This unique architecture suppresses strain‐induced percolation of conductive networks, enabling dynamic frequency tuning. It also delivers enhanced low‐frequency absorption with an effective absorption bandwidth of 2.56 GHz, covering 91% of the low‐frequency ...
Liang Li, Jiale Yan, Gengping Wan, Changlong Du, Yubing Lv, Yongzhu Yan, Zhaoyang Li, Guizhen Wang   +7 more
wiley   +1 more source

The paradox of gold-liposome nanohybrids: the location of gold governs unconventional properties and drives cellular behavior.

Mater Horiz
Mathew AP, Kandavelkumar V, Masud N, Picazo SH, Nethi SK, Uthaman S, Wen X, Huang W, Mallapragada SK, Sarkar A, Bardhan R.   +10 more
europepmc   +1 more source

Programmable π-electron quantum matter: from molecular qubits to correlated and topological states. [PDF]

Natl Sci Rev
Chi L.
europepmc   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Sequence-Encoded Frustration Directs the Formation of Abridged G-Quadruplex Architectures. [PDF]

Angew Chem Int Ed Engl
Qian Y, Ali MY, Karsisiotis AI, Dillon P, Dvorkin SA, McPherson PAC, Webba da Silva M.   +6 more
europepmc   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source