Results 51 to 60 of about 10,237,905 (234)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Network Management Protocol for Sonification of Software-Defined Infrastructures

, 2019
Network management traffic is usually carried in-band with the data plane traffic on a logically separate plane. For example, separate service queues and/or VLANs may be reserved for reliable and timely delivery of management messages.
Esposito, Flavio, Cerroni, Walter, Davoli, Gianluca   +2 more
core   +1 more source

Multi-controller Load Balancing Architecture Based on Software Defined Network [PDF]

Jisuanji gongcheng, 2016
Through the analysis of multiple of distributed architectures of Software Defined Network(SDN),a new architecture named the Distributed Control Architecture(DCA) is proposed based on SDN.DCA separates the control layer into load balancing layer and ...
ZHANG Minmin,ZHANG Yun,DUAN Yuanxin
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Joint Congestion Control Strategy in Software Defined Content Network [PDF]

Jisuanji gongcheng, 2016
Content-centric Network(CCN) provides a solution to solve the problem of content acquisition and distribution in the view of network architecture.The finiteness of network resource and unexpectedness of network traffic result in network congestion ...
ZHANG Yuncan,WANG Lei,LIU Jing,WANG Song
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Constructing Energy-Aware Software-Defined Network Virtualization

, 2015
Energy consumption, as well as carbon emission, from ITC is growing extremely. Such a growth trend therefore needs to be facilitated by the creation of an energy-efficient network as an effort in developing the future Internet.
Nguyen, Van Hong; Vietnam Research and Education Network, Nguyen, Lam Duc; Hanoi University of Science and Technology, Tran, Nam Manh; Hanoi University of Science and Technology, Nguyen, Huynh Van; Hanoi University of Science and Technology, Nguyen, Ca Van; Hanoi University of Science and Technology, Kim, Long Bao; Hanoi University of Science and Technology, Nguyen, Thanh Huu; Hanoi University of Science and Technology   +6 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

SYMPHONY - A Controller Architecture for Hybrid Software Defined Networks

, 2015
© 2015 IEEE. As enterprises migrate to SDN, a brown field network transitional state is inevitable, where both Software Defined and Legacy networks coexist.
Chemalamarri, VD, Priyadarsi Nanda, Karla Felix Navarro, Vijaya Durga Chemalamarri, Nanda, P, Navarro, KF   +5 more
core   +1 more source