Results 41 to 50 of about 38,791 (276)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Towards Quantum Satellite Internetworking: A Software-Defined Networking Perspective

IEEE Access, 2020
Recently, quantum computing and communications rapidly developed to interconnect heterogeneous quantum devices. In particular, some researchers have been performed about terrestrial quantum communications over typical optical fiber links.
Roberto Picchi, Francesco Chiti, Romano Fantacci, Laura Pierucci   +3 more
doaj   +1 more source

Industrial Networks Driven by SDN Technology for Dynamic Fast Resilience

Information, 2021
Software-Defined Networking (SDN) provides the prospect of logically centralized management in industrial networks and simplified programming among devices.
Nteziriza Nkerabahizi Josbert, Wang Ping, Min Wei, Yong Li   +3 more
doaj   +1 more source

Fast Network Configuration in Software Defined Networking [PDF]

IEEE Transactions on Network and Service Management, 2018
Software defined networking (SDN) provides a framework to dynamically adjust and re-program the data plane with the use of flow rules. The realization of highly adaptive SDNs with the ability to respond to changing demands or recover after a network failure in a short period of time, hinges on efficient updates of flow rules.
Stefan Achleitner, Novella Bartolini, Ting He, Thomas La Porta, Diman Zad Tootaghaj   +4 more
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Self-Configuration Technology for Survivability Enhancement Oriented Software Defined Networking

Journal of Harbin University of Science and Technology, 2017
Software defined networking forwards the network control plane and data plane separation，and implements programming control centralized. In view of the resource allocation problem in software defined networking environments，self-configuration technology ...
WANG Jian, LI Zhi-xin, ZHAO Guo-sheng, ZHAO Zhong-nan   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

State of the art in software defined networking (SDN)

Visión Electrónica, 2019
The growth of networks at a global level is inevitable due to the increase of users, devices and applications, such as: Internet of Things (IoT), processing and analysis of large amounts of information (Big Data), or streaming audio and video, which has ...
Miguel Ángel Barrera Pérez, Neider Yampol Serrato Losada, Elisa Rojas Sánchez, Giovani Mancilla Gaona   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source