Results 41 to 50 of about 5,927,414 (293)

An Architecture to Manage Incoming Traffic of Inter-Domain Routing Using OpenFlow Networks

Information, 2018
The Border Gateway Protocol (BGP) is the current state-of-the-art inter-domain routing between Autonomous Systems (ASes). Although BGP has different mechanisms to manage outbound traffic in an AS domain, it lacks an efficient tool for inbound traffic ...
Walber José Adriano Silva
doaj   +1 more source

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Joint Optimization on Bandwidth Allocation and Route Selection in QoE-Aware Traffic Engineering

IEEE Access, 2019
Wide area networks (WANs) are increasingly relying on software-defined networking to orchestrate data transmission. Google and Microsoft built B4 and SWAN, respectively, to interconnect their data centers in WANs, achieving higher network utilization and
Yi Wang, Jiaqi Zheng, Lijuan Tan, Chen Tian   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Enhancing the Robustness of Cyber–Physical Power Systems: Optical Configuration of Software-Defined Optical Networks

Energies
The risk of cross-domain cascading failures in cyber–physical power systems (CPPSs) has become increasingly significant. The existing studies generally employ communication networks with static routing and fixed bandwidth allocation, which are ...
Chao Fang, Yuyin Qiu, Zian Cheng, Di Xiao, Huibin Jia   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Future Scenarios for Software-Defined Metro and Access Networks and Software-Defined Photonics

Photonics, 2017
In recent years, architectures, devices, and components in telecommunication networks have been challenged by evolutionary and revolutionary factors which are drastically changing the traffic features.
Tommaso Muciaccia, Vittorio M. N. Passaro   +1 more
doaj   +1 more source

Monitoring Jitter in Software Defined Networks

, 2022
End-to-end jitter of a flow is an important metric that indicates the Quality of Service a user is experiencing, particularly for real-time applications such as video streaming, cloud gaming, and so on. Monitoring the jitter can help controllers make routing decisions for certain flows.
Jithin Kallukalam Sojan, K. Haribabu 0001   +1 more
openaire   +3 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source