Results 231 to 240 of about 14,659,030 (367)

AI-ming backwards: Vanishing archaeological landscapes in Mesopotamia and automatic detection of sites on CORONA imagery. [PDF]

PLoS One
Pistola A, Orrù V, Marchetti N, Roccetti M.   +3 more
europepmc   +1 more source

Software and Data Citation [PDF]

, 2020
Clark, Tim, Fenner, Martin, Hong, Neil P Chue, Katz, Daniel S, Martone, Maryann E   +4 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Computer-aided Nodule Detection in the Lung Apices in Head and Neck Computed Tomography Angiography: An Unexpected Opportunity. [PDF]

J Thorac Imaging
Kass TP, Chankowsky J, Sosna J, Taragin BH, Khashper A.   +4 more
europepmc   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Semi-parametric validation of genomic predictions and polygenic risk scores with the Blupf90 software suite. [PDF]

G3 (Bethesda)
Bermann M, Álvarez Múnera A, Misztal I, Lourenco D.   +3 more
europepmc   +1 more source

DREAM - an approach to designing large scale, concurrent software systems [PDF]

, 1979
Jack C. Wileden
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Multi release software reliability modelling incorporating fault generation in detection process and fault dependency with change point in correction process. [PDF]

Sci Rep
Pradhan SK, Kumar A, Kumar V.
europepmc   +1 more source