Results 51 to 60 of about 122,840 (334)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A Multi-Factor Approach for Selection of Developers to Fix Bugs in a Program

Applied Sciences, 2019
In a software tracking system, the bug assignment problem refers to the activities that developers perform during software maintenance to fix bugs. As many bugs are submitted on a daily basis, the number of developers required is quite large, and it ...
Shikai Guo, Shifei Chen, Siwen Wang, Decheng Zhang, Yaqing Liu, Chen Guo, Hui Li, Tingting Li   +7 more
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Semantic Jira - Semantic Expert Finder in the Bug Tracking Tool Jira [PDF]

, 2013
The semantic expert recommender extension for the Jira bug tracking system semantically searches for similar tickets in Jira and recommends experts and links to existing organizational (Wiki) knowledge for each ticket.
Heyn, Velten, Paschke, Adrian
core   +2 more sources

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

Enhancing Bug Localization Using Phase-Based Approach

IEEE Access, 2023
Software bug localization is an important step in the software maintenance process. Automatic bug localization can reduce the time consumed in the process of localization.
Amr Mansour Mohsen, Hesham A. Hassan, Khaled T. Wassif, Ramadan Moawad, Soha H. Makady   +4 more
doaj   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

An approach of method‐level bug localization

IET Software, 2022
Bug localization is an important field in software engineering research. The traditional bug localization approaches based on information retrieval separate words through lexical analysis.
Zhen Ni, Lili Bo, Bin Li, Tianhao Chen, Xiaobing Sun, Xiaoxue Wu   +5 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

SiameseQAT: A Semantic Context-Based Duplicate Bug Report Detection Using Replicated Cluster Information

IEEE Access, 2021
In large-scale software development environments, defect reports are maintained through bug tracking systems (BTS) and analyzed by domain experts. Different users may create bug reports in a non-standard manner and may report a particular problem using a
Thiago Marques Rocha, Andre Luiz Da Costa Carvalho   +1 more
doaj   +1 more source