Results 71 to 80 of about 5,734,084 (343)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

البرمجيات الحـــــديثة في المســــــــــح الكــــــمي للمشــــــــــــاريع الإنشــــــــــــــائية

Journal of Engineering and Sustainable Development, 2014
The engineering project management is one of the most important elements contributing to the success or failure of a business, there is no doubt about how important is the management to succeed in any area, especially in the field of construction ...
محمد مصــلح سلــمان, ســـاھرة ردیف الداغستاني   +1 more
doaj  

A Taxonomy for a Constructive Approach to Software Evolution

Journal of Software, 2007
In many software design and evaluation techniques, either the software evolution problem is not systematically elaborated, or only the impact of evolution is considered. Thus, most of the time software is changed by editing the components of the software system, i.e. breaking down the software system.
Mehmet Aksit, Pim van den Broek, Selim Ciraci   +2 more
openaire   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Public-participant quick cable force investigation method using smartphone for bridges in disaster area

Advances in Mechanical Engineering, 2016
Numerous infrastructures, especially the bridge, require some safe inspection and assessment at the soonest when hit by a disaster like catastrophic earthquake.
Xuefeng Zhao, Yanbing Ding, Yan Yu, Ruicong Han, Quanhua Guan, Weitong Hu, Mingchu Li   +6 more
doaj   +1 more source

Software engineering or methods for the multi-person construction of multi-version programs [PDF]

, 1975
David Lorge Parnas
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

MetricHunter: A software metric dataset generator utilizing SourceMonitor upon public GitHub repositories

SoftwareX, 2023
Version control systems are pervasively consulted nowadays to obtain software metric datasets. Accordingly, machine learning is applied to predict different aspects of a software including quality monitoring, influence analysis, etc.
Yusuf Özçevik, Osman Altay
doaj