Results 41 to 50 of about 175,129 (304)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Experimental Evaluation of Algorithmic Effort Estimation Models using Projects Clustering [PDF]

open access: yesJournal of Advances in Computer Engineering and Technology, 2016
One of the most important aspects of software project management is the estimation of cost and time required for running information system. Therefore, software managers try to carry estimation based on behavior, properties, and project restrictions ...
Farzaneh Famoori   +3 more
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Software maintenance cost estimation with fourth generation languages [PDF]

open access: yes, 1997
This thesis addresses the problem of allocation of software maintenance resources in a commercial environment using fourth generation language systems. The activity of maintaining software has a poor image amongst software managers, as it often appears ...
Lamb, Raymond K.
core  

USER STORY SOFTWARE ESTIMATION:A SIMPLIFICATION OF SOFTWARE ESTIMATION MODEL WITH DISTRIBUTED EXTREME PROGRAMMING ESTIMATION TECHNIQUE

open access: yesJUTI: Jurnal Ilmiah Teknologi Informasi, 2011
Software estimation is an area of software engineering concerned with the identification, classification and measurement of features of software that affect the cost of developing and sustaining computer programs [19].
Ridi Ferdiana   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

AN ENHANCED CLIENT CENTRIC SOFTWARE DEVELOPMENT LIFE CYCLE MODEL WITH COST AND EFFORT ESTIMATION [PDF]

open access: yesICTACT Journal on Management Studies, 2015
In today’s world of software development, there exist many Software Development Life Cycle (SDLC) Models. SDLC model gives a theoretical guideline for the development of the software.
Vanshika Rastogi   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

A REVIEW OF ESTIMATION OF SOFTWARE PRODUCTS DEVELOPMENT COSTS

open access: yesEkonomski Vjesnik, 2017
In the modern business and management of business processes, the standardization of procedures allows the creation of added value, increasing competitiveness and success in the business of an organization.
Edin Osmanbegović   +2 more
doaj  

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