Results 141 to 150 of about 3,419,394 (318)

Developing muscarinic receptor M1 classification models utilizing transfer learning and generative AI techniques

Scientific Reports
Muscarinic receptor subtype 1 (M1) is a G protein-coupled receptor (GPCR) and a key pharmacological target for peripheral neuropathy, chronic obstructive pulmonary disease, nerve agent exposures, and cognitive disorders.
Souvik Dey, Anders Wallqvist, Mohamed Diwan M. AbdulHameed   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Harnessing software development contexts to inform software process selection decisions [PDF]

, 2013
Software development is a complex process for which numerous approaches have been suggested. However, no single approach to software development has been met with universal acceptance, which is not surprising, as there are many different software ...
Lichter, H., Horst Lichter (12620971), O\u27Connor, Rory V., Clarke, Paul, Lepmets, Marion, Luigi Buglione (12619108), Lichter, Horst, O'Connor, Rory, O'Connor, Rory V., Paul Clake (12620968), Jeners, Simona, Buglione, Luigi, Marion Lepmets (12619684), Clake, Paul, Simona Jeners (12620788), Rory V. O'Connor (12588769)   +15 more
core  

Evolutionary success of open source software: An investigation into exogenous drivers

, 2007
Copyright @ 2007 EASSTThe “success” of a Free/Libre/Open Source Software (FLOSS) project has often been evaluated through the number of commits made to its configuration management system, number of developers and number of users.
Rank, S, Rank, Stephen, Boldyreff, Cornelia, Capiluppi, Andrea, Capiluppi, Andrea; id_orcid, Beecher, K, Beecher, Karl, Capiluppi, A, Boldyreff, C   +8 more
core   +1 more source

Intuition in software development [PDF]

, 1985
A characterization of the pervasiveness of intuition in human conscious life is given, followed by some remarks on successes and failures of intuition. Next the intuitive basis of common notions of scales, logic, correctness, texts, reasoning, and proofs, is described. On this basis the essential notions of data models of human activity and of software
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

An approach for improving the social aspects of the software development process by using a game theoretic perspective: towards a theory of social productivity of software development teams [PDF]

, 2011
As software development is considered a form of knowledge based social activity, investigating social interactions and behaviors of individuals and teams constitutes a starting point for improving organizational performance and productivity. Therefore, a
O'Connor, Rory, Yilmaz, Murat, O\u27Connor, Rory, Murat Yilmaz (58709), Rory V. O'Connor (12588769)   +4 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source