Results 171 to 180 of about 3,419,394 (318)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Lean principles applied to software development – avoiding waste [PDF]

Under the current economic conditions many organizations strive to continue the trend towards adopting better software development processes, in order to take advantage of the numerous benefits that these can offer.
Naftanaila Ionel, BRUDARU Paul
core  

Intelligent Monitoring and Dynamic Regulation Equipment and Software Development for the Equal-Pressure Fully Mechanized Mining Face in the Sandaogou Coal Mine. [PDF]

Sci Rep
Wang Z, Liu L, Yuan Q, Li W, Wang D, Zhao D, Li Y, Pan J, Qiu C.   +8 more
europepmc   +1 more source

Software development skills for health data researchers. [PDF]

BMJ Health Care Inform, 2022
Morton C, Devito N, Morley J, Dillingham I, Schultze A, Bacon S, Inglesby P, Maude S, Goldacre B.   +8 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A generative AI-driven cybersecurity framework for small and medium enterprises software development: an ANN-ISM approach. [PDF]

Sci Rep
Awan M, Alam A, Khan RA, Alwageed HS, Ayouni S, Almagrabi AO.   +5 more
europepmc   +1 more source

Editorial: Surfacing best practices for AI software development and integration in healthcare. [PDF]

Front Digit Health, 2023
Sendak M, Vidal D, Trujillo S, Singh K, Liu X, Balu S.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

How generative AI is shaping research software development and maintenance at a research-intensive university. [PDF]

Open Res Eur
Besser SA, Jensen EA, Katz DS.
europepmc   +1 more source

C2M: a maturity model for the evaluation of communication in distributed software development. [PDF]

Empir Softw Eng, 2022
Junior IF, Marczak S, Santos R, Rodrigues C, Moura H.   +4 more
europepmc   +1 more source