Results 251 to 260 of about 20,143,612 (313)
EEG as a potential ground truth for the assessment of cognitive state in software development activities: A multimodal imaging study. [PDF]
PLoS OneMedeiros J +9 more
europepmc +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
A Nationwide Chronic Disease Management Solution via Clinical Decision Support Services: Software Development and Real-Life Implementation Report. [PDF]
JMIR Med InformUlgu MM +13 more
europepmc +1 more source
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Jidoka in software development
Companion to the 23rd ACM SIGPLAN conference on Object-oriented programming systems languages and applications, 2008Lean management is based on two concepts: the elimination of Muda, the waste, from the production process, and Jidoka, the introduction of quality inside the production process and product. In software production, the elimination of Muda received significant attention, while Jidoka has not yet been fully exploited.
Emanuele Danovaro +2 more
openaire +3 more sources
Postmodern Software Development
The Computer Journal, 1998We discuss the ‘software crisis’ as a social and cultural phenomenon, arguing that it can be viewed as (one more) manifestation of postmodernism. We illustrate our argument with a range of examples taken from software engineering, demonstrating software engineering’s roots in ...
Hugh Robinson +3 more
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Understanding Software Engineers’ Skill Development in Software Development
Journal of Computer Information Systems, 2019Organizations increasingly use virtual teams to support their business processes. With software development as its context, this study aims to examine how software engineers are motivated to work i...
Xuequn Wang, Xiaolin Lin, Nick Hajli
openaire +2 more sources