Results 121 to 130 of about 25,098,289 (293)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

A comparative study of Software Development Life Cycle (SDLC) models [PDF]

Software Development life cycle (SDLC) is a framework model used in project management that defines the stages included in an information system and a software development project, from an initial feasibility study to the maintenance of the completed ...
Bajrami, Buen, Jolevski, Ilija, Veljanovska, Kostandina   +2 more
core  

Programming Language Selection for The Development of Deep Learning Library

JOIV: International Journal on Informatics Visualization
Recently, deep learning has become very successful in various applications, leading to an increasing need for software tools to keep up with the rapid pace of innovation in deep learning research.
Oktavia Citra Resmi Rachmawati, Ali Ridho Barakbah, Tita Karlita   +2 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Using Axiomatic Design and Fuzzy Axiomatic Design for Risk Management in Software Development

IEEE Access
The software development process is a type of structural approach, also called the software development life cycle, that includes many different steps including planning, requirements analysis, design, implementation, testing, deployment and maintenance,
Taner Behcet Kepkep, Alptekin Durmusoglu, Turkay Dereli   +2 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Project Management Life Cycle Approaches For Software Development [PDF]

The project from its beginning to its finalization goes through different phases that together form the so-called project life cycle. The paper analyzes four basic project management life cycle approaches that are applied especially in the management ...
Angeleski, Marjan, Zdraveski, Dejan, Kostoska, Olivera   +2 more
core  

Risk Identification and Preemptive scheduling in Software Development Life Cycle [PDF]

, 2010
Software development has emerged as a disciplined discipline and the use of process models to develop the software has increased over time. Although the software industry is blessed with quite a few tool driven approaches, and the usage of technology is ...
Basit Shahzad, , Abdullah S. Al-Mudimigh,, Zahid Ullah, Abdullah S. Al-Mudimigh, Dr. Basit Shahzad, Al-Mudimigh   +5 more
core  

Pengembangan Sistem Informasi Pengelolaan Beasiswa Politeknik Caltex Riau

Jurnal Komputer Terapan
Politeknik Caltex Riau mengelola beberapa beasiswa yang sumber pendanaannya bisa berasal dari pemerintah maupun swasta. Pengelolaan skema beasiswa ini dilakukan secara manual berupa pengumpulan berkas dan rekap melalui Ms. Excel.
Satria Perdana Arifin, zainal Arifin Renaldo, Ibnu Surya   +2 more
doaj   +1 more source