Results 211 to 220 of about 29,727,043 (291)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Mapping a differentiation architecture for hard tissue mineralization with large-scale single-cell atlases. [PDF]

PLoS Comput Biol
Han L, Yu Y, Feng M, Lin Z, Wang Y, Xia T, Fan Q, Liu H, Wei Y, Zhang Y.   +9 more
europepmc   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Methodologies for generating and evaluating clinical and performance evidence for high-risk and innovative medical devices and <i>in vitro</i> diagnostics: a scoping review. [PDF]

Front Med Technol
Bralić N, Bandić R, Vuković M, Matijaca D, Valsami R, Zoumpoulakis P, Schnitzer K, Levula M, Roine R, Viitala A, Pihlava A, McDermott O, Marušić A.   +12 more
europepmc   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

BAM15 Enhances Regorafenib Cytotoxicity in a Canine Osteosarcoma Cell Model. [PDF]

Int J Mol Sci
Dolnicka A, Marcinkowska K, Obmińska-Mrukowicz B, Fosse V, Raciborska A, Śmieszek A.   +5 more
europepmc   +1 more source

Thermomechanical Fatigue and Creep–Fatigue Interaction of Inconel 718 Additively Manufactured by Laser Beam Powder Bed Fusion

Advanced Engineering Materials, EarlyView.
Thermomechanical fatigue tests of laser beam powder bed fusion (PBF‐LB) Inconel 718 show that the additively manufactured material reaches almost the lifetimes of conventionally‐rolled material under no‐dwell conditions. Introducing dwell times at the maximum temperature markedly reduces the lifetimes due to pronounced grain boundary sliding associated
Stefan Guth, Tomáš Babinský, Jan Lars Riedel, Wen Hao Kan, Aijun Huang, Martin Heilmaier, Ivo Šulák   +6 more
wiley   +1 more source

TRAFFICGEN: a multi-agent LLM orchestration for smart mobility and emergency corridor pre-emption. [PDF]

Front Artif Intell
Soni G, Khekare G, Kumar Y, Rupaak S.
europepmc   +1 more source

Electrochemical Behavior of Flame‐Sprayed Sc‐Doped AlCoCrFeMo High‐Entropy Alloy Coatings in 3.5% Sodium Chloride Solution

Advanced Engineering Materials, EarlyView.
Scandium (Sc)‐doped AlCoCrFeMo HEA coatings are fabricated via flame spraying with 0.1, 0.3, and 0.5 wt% Sc additions. Among these, the HEA‐Sc0.3 coating exhibits the highest corrosion resistance, indicated by a more positive corrosion potential and lower current density.
Pankaj Kumar, Akash Vyas, Mohammad Aatif Qazi, Nashit Jalal, Maria Ophelia Jarligo, Mostafa Yakout, Jing Liu, André McDonald   +7 more
wiley   +1 more source

FuChi is a cell cycle biosensor for tracking cell cycle dynamics during avian development. [PDF]

PLoS Biol
Sudderick ZR, Briggs T, Mubarak S, Van Kerckvoorde M, Hernandez Rodriguez AR, Panda SK, Riddell J, Batho-Samblas C, Taylor L, McTeir L, Meunier D, Findlay A, Roberts FS, Raper A, Sakaue-Sawano A, Miyawaki A, Rainger J, Schoenebeck JJ, Weijer CJ, McGrew MJ, Headon DJ, Davey MG, Mort RL, Glover JD.   +23 more
europepmc   +1 more source