Results 121 to 130 of about 2,082,662 (312)

An Empirical Study of a Software Maintenance Process [PDF]

, 1996
This paper describes how a process support tool is used to collect metrics about a major upgrade to our own electronic retail system. An incremental prototyping lifecycle is adopted in which each increment is categorised by an effort type and a project ...
Phalp, K. T., Smith, A.P., Smith, A. P., Phalp, Keith T., Harrison, R., Nithi, R., Samaraweera, L. G., Harrison, Rachel, Samaraweera, L.G.   +8 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Process Models and Distribution of Work in Offshoring Application Software Development [PDF]

Common process models for the development of application software (AS) are examined as to how well they are suited for offshoring projects. The need for communication and interaction among onsite and offshore project stakeholders is identified as a ...
Kurbel, Karl
core  

A hierarchy of SPI activities for software SMEs: results from ISO/IEC 12207-based SPI assessments [PDF]

, 2012
In an assessment of software process improvement (SPI) in 15 software small- and –medium-sized enterprises (software SMEs), we applied the broad spectrum of software specific and system context processes in ISO/IEC 12207 to the task of examining SPI in ...
Paul Clarke, O'Connor, Rory, O'Connor, Rory V., Yilmaz, Murat, O\u27Connor, Rory V., Clarke, Paul, O\u27Connor, Rory, Rory V. O’Connor, Paul Clarke (26935), Murat Yilmaz, Rory V. O'Connor (12588769), Murat Yilmaz (58709)   +11 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A Flexible Software Process Model [PDF]

, 2004
The development of software products is a complex activity with a large number of factors involved in defining success. As real-world experimentation is difficult and costly, researchers have used various techniques in an attempt to model the development
Kirk, Dianna
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

automated process quality assurance for distributed software development [PDF]

, 2009
As required or implicated in many process improvement or assessment models, Process Quality Assurance (PQA) is introduced to objectively evaluate actual software processes against applicable processes descriptions, standards, and procedures ...
Yang Qiusong, Xiao Junchao, Wang Qing, Yang Ye, Li Mingshu, Zhai Jian   +5 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Software development process improvement : an approach involving innovation and knowledge management [PDF]

, 2010
Mestrado em Engenharia e Gestão IndustrialEste trabalho, organizado em torno de três artigos, tem como objectivo contribuir para a melhoria do processo de desenvolvimento de software através das práticas de gestão do conhecimento (GC), da inovação e de ...
Fedotova, Olga Volodymyrivna
core   +1 more source