Results 181 to 190 of about 8,268,032 (366)
Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers +9 morewiley +1 more sourceRIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz +9 morewiley +1 more sourceCOMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom +6 morewiley +1 more sourcePeer Review #1 of "Happy software developers solve problems better: psychological measurements in empirical software engineering (v0.1)"
, 2014 Daniel Graziotin, Xiaofeng Wang, Pekka Abrahamsson, Abele-Brehm A, T Amabile, T Amabile, T Amabile, S Barsade, J Mueller, B Staw, M Baas, De Dreu, Ckw Nijstad, B, S Barsade, D Gibson, K Beck, M Beedle, A Bennekum, A Cockburn, W Cunningham, M Fowler, Thomas, D, P Berander, C Berna, S Leknes, E Holmes, R Edwards, G Goodwin, I Tracey, B Boehm, P Papaccio, S Brand, T Reimer, K Opwis, C Ciborra, A Cockburn, J Highsmith, R Colomo-Palacios, J Cortina, J Crawford, J Henry, L Cronbach, A Cropley, M Csikszentmihalyi, D Darcy, M Davis, P Denning, E Diener, E Suh, R Lucas, H Smith, E Diener, D Wirtz, W Tov, C Kim-Prieto, D Choi, S Oishi, R Biswas-Diener, T Dogan, T Totan, F Sapmaz, T Dyba, R Feldt, L Angelis, R Torkar, M Samuelsson, R Feldt, R Torkar, L Angelis, M Samuelsson, G Fischer, Cd ; Fisher, C Fisher, N Ashkanasy, C Fong, M Forgeard, J George, J Zhou, R Glass, I Vessey, S Conger, D Graziotin, X Wang, P Abrahamsson, M Hst, B Regnell, C Wohlin, J Hughes, C Stoney, R Ilies, T Judge, J Kaufman, J Lee, J Baer, S Lee, G Kaufmann, S Vosburg, I Khan +99 moreopenalex +2 more sourcesPre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan +11 morewiley +1 more sourceEngineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more source