Results 251 to 260 of about 829,080 (295)

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang   +16 more
wiley   +1 more source

Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin   +10 more
wiley   +1 more source

Cognitive Impairment in Multiple Sclerosis: The Role of Clinical and Sociodemographic Factors ‐ A Systematic Review and Meta‐Analysis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment (CI) affects the quality of life in multiple sclerosis (MS). Identifying influencing factors is key to improving CI monitoring. This systematic review and meta‐analysis examines clinical and sociodemographic variables impacting the cognitive screening Symbol Digit Modalities Test (SDMT) performance across MS ...
Katalin Lugosi   +8 more
wiley   +1 more source

Software and Software Engineering

SIAM Review, 1973
First, we give a short account of the preclassical (Babbage, Ludgate) and classical (Zuze, von Neumann, Wilkes) initial steps in establishing programming concepts. The net result of the 1945–1955 decade was a thorough underestimate of the role software would play in the next decade.
openaire   +3 more sources

The software engineering of internet software

IEEE Software, 2002
0 7 4 0 7 4 5 9 / 0 2 / $ 1 7 . 0 0 © 2 0 0 2 I E E E M a r c h / A p r i l 2 0 0 2 I E E E S O F T W A R E 2 3 The real departure for Web-based enterprise applications is the possibility of wideranging accessibility. A system that might be deployed in-house at a manufacturing company can now be deployed to all the dealers of that manufacturer’s ...
E. Hendrickson, Martin Fowler
openaire   +2 more sources

Engineering Software & Software Engineering

1998
Software has become an indispensable part of most products and services. As a result the need to “engineer software” professionally with high quality at low cost has become important to all branches of industry. The supporting scientific discipline called “software engineering”, on the other hand, has matured very slowly, and has only just now arrived ...
Dieter Rombach, Dieter Rombach
openaire   +2 more sources

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