Results 91 to 100 of about 1,880,655 (305)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Geogebra for strengthening spatial thinking in Differential Calculus

Revista Ingenio, 2017
Evidenced of weaknesses in the learning process of differential calculus in Engineering students at the Francisco de Paula Santander Ocaña University, it was sought to organize a group of teachers and students in a Learning Community and a Mathematics ...
Henry Carrascal Carrascal, Jorge Ernesto Chaves Peña, Malka Irina Cabellos Martínez   +2 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Complexity Quantification for Overhead Transmission Line Emergency Repair Scheme via a Graph Entropy Method Improved with Petri Net and AHP Weighting Method

Discrete Dynamics in Nature and Society, 2014
According to the characteristics of emergency repair in overhead transmission line accidents, a complexity quantification method for emergency repair scheme is proposed based on the entropy method in software engineering, which is improved by using group
Jing Zhou, Cunbin Li, Weihua Shen, Ye Zhang   +3 more
doaj   +1 more source

Podcasting, pupils and pre-service-teachers [PDF]

, 2008
This Action Research conforms to Cohen's definition (2000) as "small scale intervention in the functioning of the real world and a close examination of the effects of such an intervention." It is a pilot study that uses a small, but representative group ...
Muir, David, Souter, Nicholas
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

PENGARUH PENGGUNAAN ACTION CAM TERHADAP KUALITAS PENILAIAN PROSES DOSEN PRAKTIKUM [PDF]

, 2015
The assessment systemsoflecturer practice in the Department of Mechanical Engineering Education atUniversity of Sarjanawiyata Tamansiswa still using the conventional method of direct observation.
Bayu Rahmat Setiadi, FKIP UST, Dianna Ratnawati, FKIP UST, Sulaeman Deni Ramdani, Program Pascasarjana Universitas Negeri Yogyakarta   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Status report: specifying JavaScript with ML [PDF]

, 2007
The Ecma TC39-TG1 working group is using ML as the specification language for the next generation of JavaScript, the popular programming language for browser-based web applications.
David Herman
core   +1 more source