Results 111 to 120 of about 1,694,387 (293)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

An investigation into artificial intelligence based generative computer process planning [PDF]

open access: yes, 1995
The process planning function can be further optimized with the introduction of an intelligent software package such as an Artificial Intelligence based Generative Computer Process Planning System.
Tereshkovich, William
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Evaluating the Applicability of Requirements Engineering Tools for Distributed Software Development [PDF]

open access: yes, 2007
Requirements engineering (RE) is the first part of the software engineering process. It consists of distinct phases in which certain stakeholders deal with the problem of creating and maintaining a systems requirements document.
Geisser, Michael   +2 more
core  

Integration of Simulink Models with Component-based Software Models

open access: yesAdvances in Electrical and Computer Engineering, 2008
Model based development aims to facilitate the development of embedded control systems by emphasizing the separation of the design level from the implementation level.
MARIAN, N., TOP, S.
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Development of Interactive Materials by Engineering Students Using the Descartes Applets.

open access: yes, 2011
In a degree course such as Forestry Engineering, the general teaching objectives consist of explaining and helping students to understand the principles of Mechanics.
Ayuga Téllez, Esperanza   +3 more
core  

An investigation of the utility and value of process patterns in the management of software development projects. [PDF]

open access: yes, 2008
Pattern theory has engendered much controversy in the field of architecture; yet it has brought new insights to the field of software engineering.
Estabraghy, A., Estabraghy, A.
core  

Estudio sobre realización y documentación de pruebas software

open access: yesMaskana, 2015
RESUMEN El presente trabajo describe el proceso realizado y resultados obtenidos al estudiar la documentación técnica de los desarrollos de software (DS) del grupo de investigación en sistemas y tecnologías de la información (STI), grupo adscrito a la ...
Diego Armando Villareal Diaz   +2 more
doaj  

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