Results 121 to 130 of about 1,880,655 (305)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Negotiated assessment criteria and peer assessment in software engineering group project work: A case study [PDF]
, 1999 The core second level course in Software Engineering for Computer Science students at the University of Kent has, for many years, included a substantial design-and-build group project component. In recent years, this has been enhanced to address a number
Utting, Ian
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Real-Time Classroom Behavior Analysis for Enhanced Engineering Education: An AI-Assisted Approach
International Journal of Computational Intelligence SystemsModern teaching has made significant progress, with many advanced equipment and technologies being introduced into the teaching process. Experimental teaching of engineering design courses is important.
Jia Hu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Journal of Multidisciplinary Healthcare, 2018 Charic D Farinango,1 Juan S Benavides,1 Jesús D Cerón,1 Diego M López,1 Rosa E Álvarez2 1Telematics Engineering Research Group, Faculty of Electronics and Telecommunications Engineering, Universidad del Cauca, Popayán ...
Farinango CD +4 more
doaj
Industry-driven innovative system development for the construction industry: The DIVERCITY project [PDF]
, 2004 Collaborative working has become possible using the innovative integrated systems in construction as many activities are performed globally with stakeholders situated in various locations.
Aouad, GF, Arayici, Y
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Game-Based Learning in Engineering Education [PDF]
, 2008 The new generation of undergraduates entering UK higher education have grown up with computer games of ever increasing sophistication. In this educational project a race game, Racing Academy, was developed to investigate how game technology and gaming ...
Darling, Jos +4 more
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