Results 121 to 130 of about 1,694,387 (293)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Developing a Model-Driven Reengineering Approach for Migrating PL/SQL Triggers to Java: A Practical Experience [PDF]

, 2019
©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Submitted Manuscript version of a Published Work that appeared in final form in Journal of Systems
Bermúdez Ruiz, Francisco Javier, Cuesta Viera, Benito José, Fernández Candel, Carlos, García Molina, Jesús J., Hoyos Barceló, José Ramón, Sevilla Ruiz, Diego   +5 more
core  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Logistics engineering curriculum integrated through student projects [PDF]

, 2011
This paper describes an innovative curriculum developed for new Logistics Engineering degree programs at the Faculty of Engineering Management, Poznan University of Technology.
Pasek, Zbigniew, Pawlewski, P.
core   +1 more source

Development of a software architecture for bioprocess modeling

Digital Chemical Engineering
Increasing the productivity of a biotechnological process becomes feasible through the development of Process Systems Engineering tools, which integrate experimental data with mathematical modeling.
Priscila Marques da Paz, Caroline Satye Martins Nakama, Galo Antonio Carrillo Le Roux   +2 more
doaj  

The effect of 3D visualization on mainframe application maintenance: A controlled experiment

Journal of King Saud University: Computer and Information Sciences, 2019
Code written in 1960’s and 80’s are still being maintained by large software organizations. Such legacy systems play a significant role in supporting various data immense applications in banking, manufacturing, retail marketing, health care domains etc ...
C.J. Satish, Anand Mahendran
doaj  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Building Student Teams: A Self-Managed Work Team (SMWT) Cooperative Learning Model [PDF]

, 1997
This paper examines the team formation process which can beemployed when utilizing group projects in information system (IS) classes. The paper presents a model for building team skills, creating positive interdependence, individual accountability, and ...
Case, Carl J.
core   +1 more source

Human-centered design of a personal health record system for metabolic syndrome management based on the ISO 9241-210:2010 standard

Journal of Multidisciplinary Healthcare, 2018
Charic D Farinango,1 Juan S Benavides,1 Jesús D Cerón,1 Diego M López,1 Rosa E Álvarez2 1Telematics Engineering Research Group, Faculty of Electronics and Telecommunications Engineering, Universidad del Cauca, Popayán ...
Farinango CD, Benavides JS, Cerón JD, López DM, Álvarez RE   +4 more
doaj