Results 131 to 140 of about 1,694,387 (293)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Real-Time Classroom Behavior Analysis for Enhanced Engineering Education: An AI-Assisted Approach

International Journal of Computational Intelligence Systems
Modern teaching has made significant progress, with many advanced equipment and technologies being introduced into the teaching process. Experimental teaching of engineering design courses is important.
Jia Hu, Zhenxi Huang, Jing Li, Lingfeng Xu, Yuntao Zou   +4 more
doaj   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Focus group: cost-effective and methodologically sound ways to get practitioners involved in your empirical RE research [PDF]

, 2015
Focus groups are a qualitative research method helping researchers collect and analyze information from practitioners in industry, in order to better understand how a Requirements Engineering (RE) phenomenon happens from the perspective of those working ...
Daneva, Maya
core   +2 more sources

An Innovative STEAM-Based Method for Teaching Cycloidal Curves in Engineering Higher Education

Education Sciences
Robotics offers innovative possibilities at all levels of education, which should be considered when planning the teaching process for certain engineering mathematics topics in higher education.
Szilvia Szilágyi, Attila Körei, Ingrida Vaičiulyté   +2 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Towards Experience Management for Very Small Entities

, 2011
International audienceThe ISO/IEC 29110 standard: Lifecycle profiles for Very Small Entities, provides several Process Reference Models applicable to the vast majority of very small entities (defined by the ISO as "an entity (enterprise, organization ...
Laporte, Claude, Ribaud, Vincent, Saliou, Philippe   +2 more
core   +2 more sources

Metrics for the Case Management Modeling and Notation (CMMN) Specification [PDF]

, 2015
General and reference Metrics; Applied com- puting Business process modeling; Software and its engineering System modeling languages; Computing methodologies Model veri cation and validation;The Case Management Modeling and Notation (CMMN ...
Lotriet, Hugo, Marin, Mike A, Van Der Poll, John A   +2 more
core   +1 more source

Introducing process simulation as an alternative to laboratory session in undergraduate chemical engineering thermodynamics course: A case study from Sunway University Malaysia

Digital Chemical Engineering
This study demonstrates the successful integration of process simulation using CHEMCAD into Sunway University's Chemical Engineering Thermodynamics curriculum, replacing the traditional lab sessions. This approach has two main benefits, i.e., it provides
Zong Yang Kong, Abdul Aziz Omar, Sian Lun Lau, Jaka Sunarso   +3 more
doaj  

The Success of Software Support in Engineering: An Emphasis on Process Rather Than Product

Acta Polytechnica, 2000
There is a need for technological computerized support systems to supplement the structure and process of communication within the multi-disciplinary design team rather than attempt to substitute it.
A. Whyte, H. M. Edge, A. AL-Hajj
doaj