Results 51 to 60 of about 1,694,387 (293)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Learning Software Development through Modeling using an Object Oriented Approach with Unified Modeling Language: A Case of an Online Interview System

Journal of Learning for Development, 2021
This paper demonstrates the learning of software engineering through modeling using Object-Oriented Analysis and Design approach with Unified Modeling Language.
Ellen Ambakisye Kalinga
doaj  

Collaborative Modeling of Group Learning Applications Using Eclipse Technology

Proceedings, 2019
The design and creation of groupware tools is a complex task that usually requires the participation of different stakeholders (software engineers, designers, etc.), either working at the same time or collaborating asynchronously. This paper describes an
Yoel Arroyo, Ana I. Molina, Miguel A. Redondo, Jesús Gallardo, Carmen Lacave   +4 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

An Ontological Behavioral Modeling Approach With SHACL, SPARQL, and RDF Applied to Smart Grids

IEEE Access
Every engineering process, especially software, involves two complementary aspects: structural and behavioral. Behavior is, in essence, transforming the structure associated with the system.
Mohamed Larhrib, Miguel Escribano, Carlos Cerrada, Juan Jose Escribano   +3 more
doaj   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

A self-organising awareness system for distributed software engineering [PDF]

, 2004
Software engineers and other collaborative disciplines rely on informal "out-of-band" communication for ef- fective coordination of their activities, especially in agile methods.
Nutter, David
core  

BUILDING THE PROFESSIONAL COMPETENCE OF FUTURE PROGRAMMERS USING METHODS AND TOOLS OF FLEXIBLE DEVELOPMENT OF SOFTWARE APPLICATIONS

Інформаційні технології і засоби навчання, 2022
To support their professional expertise, a modern programmer must constantly follow new technologies, learn new methods of solving problems (best practices), exchange experience, use auxiliary tools that accelerate the development process, should be ...
Олена Григорівна Глазунова, Олександра В’ячеславівна Пархоменко, Валентина Ігорівна Корольчук, Тетяна Володимирівна Волошина   +3 more
doaj   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source