Results 61 to 70 of about 1,880,655 (305)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Managing human-AI collaborations within Industry 5.0 scenarios via knowledge graphs: key challenges and lessons learned

Frontiers in Artificial Intelligence
In this paper, we discuss technologies and approaches based on Knowledge Graphs (KGs) that enable the management of inline human interventions in AI-assisted manufacturing processes in Industry 5.0 under potentially changing conditions in order to ...
Franz Krause, Heiko Paulheim, Elmar Kiesling, Kabul Kurniawan, Kabul Kurniawan, Maria Chiara Leva, Hector Diego Estrada-Lugo, Gernot Stübl, Nazim Kemal Üre, Javier Dominguez-Ledo, Maqbool Khan, Maqbool Khan, Pedro Demolder, Hans Gaux, Bernhard Heinzl, Thomas Hoch, Jorge Martinez-Gil, Agastya Silvina, Bernhard A. Moser   +18 more
doaj   +1 more source

On the hardware and software architecture of the robuter mobile platform: a hands-on approach [PDF]

, 2005
The Robuter is a robotic mobile platform that is located in the “Hands-On” Laboratory of the IPP-Hurray! Research Group, at the School of Engineering of the Polytechnic Institute of Porto.
Alves, Mário, Lomba, Emmanuel
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Introducing process simulation as an alternative to laboratory session in undergraduate chemical engineering thermodynamics course: A case study from Sunway University Malaysia

Digital Chemical Engineering
This study demonstrates the successful integration of process simulation using CHEMCAD into Sunway University's Chemical Engineering Thermodynamics curriculum, replacing the traditional lab sessions. This approach has two main benefits, i.e., it provides
Zong Yang Kong, Abdul Aziz Omar, Sian Lun Lau, Jaka Sunarso   +3 more
doaj   +1 more source

Application of professional standards for training in methods and technologies of software engineering at the higher education institutions

Открытое образование (Москва), 2018
The research is devoted to the analysis of professional standards in the course “information technologies”, its interaction and correlation with federal state educational standards of higher education.
A. S. Minzov, O. I. Melnikova
doaj   +1 more source

Science & engineering software migration: moving from desktop to mobile applications [PDF]

, 2013
The proliferation of mobile devices over the last years provides opportunities and challenges for solving problems in Science & Engineering. Among other novel features, mobile devices contain global positioning sensors, wireless connectivity ...
Améndola, Federico, Favre, Liliana María   +1 more
core   +1 more source

Summary of the First Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE1) [PDF]

, 2014
Challenges related to development, deployment, and maintenance of reusable software for science are becoming a growing concern. Many scientists’ research increasingly depends on the quality and availability of software upon which their works are built ...
Allen, Gabrielle D., Berriman, Bruce, Choi, Sou-Cheng T., Elster, Anne C., Hanwell, Marcus D., Hetherington, James, Howison, James, Katz, Daniel S., Lapp, Hilmar, Löffler, Frank, Maheshwari, Ketan, Swenson, Shel, Turk, Matthew, Venters, Colin, Wilkins-Diehr, Nancy   +14 more
core   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source