Results 81 to 90 of about 1,880,655 (305)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Formulating an Engineering Framework for Future AI Certification in Aviation

Aerospace
A continuous increase in artificial intelligence (AI)-based functions can be expected for future aviation systems, posing significant challenges to traditional development processes.
Johann Maximilian Christensen, Thomas Stefani, Akshay Anilkumar Girija, Elena Hoemann, Andrea Vogt, Viktor Werbilo, Umut Durak, Frank Köster, Thomas Krüger, Sven Hallerbach   +9 more
doaj   +1 more source

The Software Engineering Laboratory: An operational software experience factory [PDF]

For 15 years, the Software Engineering Laboratory (SEL) has been carrying out studies and experiments for the purpose of understanding, assessing, and improving software and software processes within a production software development environment at NASA ...
Basili, Victor R., Caldiera, Gianluigi, Mcgarry, Frank, Page, Gerald, Pajerski, Rose, Waligora, Sharon   +5 more
core   +1 more source

GIS and Introductory Environmental Engineering: A Way to Fold GIS into an Already-Existing Course [PDF]

, 2013
The use of Geographical Information Systems (GIS) was implemented in the upper-division undergraduate technical elective Introduction to Environmental Engineering at Harvey Mudd College.
Cardenas, Mary P., Kelley, David Wayne, Roberts, Warren   +2 more
core   +1 more source

On Integrating Student Empirical Software Engineering Studies with Research and Teaching Goals [PDF]

, 2012
Background: Many empirical software engineering studies use students as subjects and are conducted as part of university courses. Aim: We aim at reporting our experiences with using guidelines for integrating empirical studies with our research and ...
Avgeriou, Paris,, Galster, Matthias,, Tofan, Dan,   +2 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Ada education in a software life-cycle context [PDF]

Some of the experience gained from a comprehensive educational program undertaken at The Charles Stark Draper Lab. to introduce the Ada language and to transition modern software engineering technology into the development of Ada and non-Ada applications
Clough, Anne J.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

DEVELOPING SOFTWARE ENGINEERING STUDENTS’ READINESS FOR PROFESSIONAL MOBILITY THROUGH BLENDED LEARNING

Novìtnâ Osvìta, 2019
The article aims to study the formation of the software engineering students’ readiness for professional mobility in the educational and information environment of a technical university.
Elvira Luzik, Oleksandra Akmaldinova, Larysa Tereminko   +2 more
doaj   +1 more source

Microdevices for Continuous Sized Based Sorting by AC Dielectrophoresis [PDF]

, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014), Altinagac, E, Beskok, A, Genc, Y, Kizil, H, Trabzon, L   +5 more
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