Results 151 to 160 of about 252,658 (290)

Peer Review #1 of "On the impact of service-oriented patterns on software evolvability: a controlled experiment and metric-based analysis (v0.1)"

, 2019

openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Uncovering Scientific Software Sustainability through Community Engagement and Software Quality Metrics [PDF]

Sharif Ahmed, Addi Malviya Thakur, Gregory R. Watson, Nasir U. Eisty   +3 more
openalex   +1 more source

When do Software Complexity Metrics Mean Nothing? – When Examined out of Context. [PDF]

, 2016
Joseph A. Gil, Gal Lalouche
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

CENTRA: knowledge-based gene contextuality graphs reveal functional master regulators by centrality and fractality. [PDF]

NAR Genom Bioinform
Hause F, Wedler A, Keil R, Schian L, Glaß M, Grimm WF, Sorokin O, Hoehenwarter W, Sinz A, Hüttelmaier S.   +9 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Software Metrics

, 2015
openaire   +2 more sources

Improvement of magnetic resonance imaging diffusion metric 'slow diffusion coefficient (SDC)' over apparent diffusion coefficient (ADC) for isocitrate dehydrogenase (IDH) genotyping in diffuse gliomas. [PDF]

Quant Imaging Med Surg
Zheng WY, Shi YT, He YY, Lin RL, Xiao BH, Jiang RF, Wáng YXJ.   +6 more
europepmc   +1 more source

Improving predictive models of software quality using search-based metric selection and decision trees

, 2010
Rodrigo Vivanco
openalex   +1 more source