Results 61 to 70 of about 3,700,849 (335)
Evaluation of Classifiers in Software Fault-Proneness Prediction [PDF]
Journal of Artificial Intelligence and Data Mining, 2017 Reliability of software counts on its fault-prone modules. This means that the less software consists of fault-prone units the more we may trust it. Therefore, if we are able to predict the number of fault-prone modules of software, it will be possible ...
F. Karimian, S. M. Babamir
doaj +1 more source
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Not all sequence tags are created equal: designing and validating sequence identification tags robust to indels. [PDF]
PLoS ONE, 2012 Ligating adapters with unique synthetic oligonucleotide sequences (sequence tags) onto individual DNA samples before massively parallel sequencing is a popular and efficient way to obtain sequence data from many individual samples.
Brant C Faircloth, Travis C Glenn
doaj +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
What Happened to Software Metrics? [PDF]
Computer, 2017 A panel of seven experts discuss the past 40 years of software metrics, with a focus on evidence-based methods.
Jeffrey Voas, D. Richard Kuhn
openaire +3 more sources
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Computation of the Approximate Symmetric Chordal Metric for Complex Numbers
MathematicsThe basic theoretical properties of the approximate symmetric chordal metric (ASCM) for two real or complex numbers are studied, and reliable, accurate, and efficient algorithms are proposed for its computation. ASCM is defined as the minimum between the
Vasile Sima
doaj +1 more source
Managing Web Service Interface Complexity via an OO Metric-based Early Approach
CLEI Electronic Journal, 2017 Web Services have been steadily gaining maturity as their adoption in the software industry grew. Accordingly, metric suites for assessing different quality attributes of Web Service artifacts have been proposed recently - e.g., for services interfaces ...
Cristian Mateos +4 more
doaj +1 more source