Results 221 to 230 of about 997,849 (284)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A Tutorial on Sample Size Calculation for Inter-rater and Intra-rater Agreement Studies. [PDF]

Indian J Psychol Med
Madadizadeh F, Bahariniya S.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Unbiased quantification of persistent postural and motor deficits following spinal cord injury in mice. [PDF]

PLoS One
Jobbins SS, Pande V, Zeng CW, Poldsam H, Pool AH, Zhang CL, Lai HC.   +6 more
europepmc   +1 more source

PET rapid image reconstruction challenge (PETRIC). [PDF]

Front Nucl Med
da Costa-Luis C, Ehrhardt MJ, Kolbitsch C, Ovtchinnikov E, Pasca E, Thielemans K, Tsoumpas C.   +6 more
europepmc   +1 more source

Metapipeline-DNA: A comprehensive germline and somatic genomics Nextflow pipeline. [PDF]

Cell Rep Methods
Patel Y, Zhu C, Yamaguchi TN, Wang NK, Wiltsie N, Zeltser N, Gonzalez AE, Winata HK, Pan Y, Mootor MFE, Sanders T, Fitz-Gibbon ST, Kandoth C, Livingstone J, Liu LY, Carlin B, Holmes A, Oh J, Sahrmann J, Tao S, Eng S, Hugh-White R, Pashminehazar K, Beshlikyan A, Jordan M, Wu S, Tian M, Arbet J, Neilsen B, Haas R, Bugh YZ, Kim G, Salmingo J, Zhang W, Anand A, Hwang E, Neiman-Golden A, Steinberg P, Zhao W, Anand P, Agrawal R, Tsai BL, Boutros PC.   +42 more
europepmc   +1 more source

AI-based planning for DIEAP flap procedures: exploring foundation models for artery perforators analysis. [PDF]

Front Med (Lausanne)
Andrade M, Loução N, Pinto D, Marques T, Vigário R, Gouveia P, Santinha J.   +6 more
europepmc   +1 more source

Machine learning-based ground motion simulation for seismic hazard assessment of critical water infrastructure in Azerbaijan (Case study: Major Shamkir water reservoir). [PDF]

PLoS One
Babayev T, Babayev G, Bayramov E, Irawan S, Neafie J, Aliyeva S.   +5 more
europepmc   +1 more source