Results 271 to 280 of about 4,534,833 (370)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Benchmarking informatics workflows for data-independent acquisition single-cell proteomics. [PDF]

Nat Commun
Wang J, Huang Y, Lu F, Xu Q, Yang Z, Jiang Y, Shi S, Pan J, Yang Y, Fang Q.   +9 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Microbiota discovered in scorpion venom. [PDF]

PLoS One
Murdoch B, Kleinschmit AJ, Santibáñez-López CE, Graham MR.   +3 more
europepmc   +1 more source

Code and Performance-based Metrics for Multithreaded Object-Oriented Software

R. Gururaj, T. Kalpalatha Reddy, Revanth Nalla   +2 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

High effectiveness of the digitalization of the GESIDA clinical guideline for HIV patient management. [PDF]

BMC Health Serv Res
Montosa-I-Micó V, Tortajada C, Batet ÁN, Castillo RA, Camacho M, Perez DR, García DS, García-Gómez JM.   +7 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Artificial intelligence in emergency department triage: perspective of human professionals. [PDF]

Front Digit Health
Petrica A, Marza AM, Barsac C, Cebzan A, Dragan I, Zaharie D, Horhat R, Lungeanu D.   +7 more
europepmc   +1 more source