Results 281 to 290 of about 4,366,415 (378)

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Intervertebral disc anomaly intelligent classification system based on deep learning, IDAICS. [PDF]

Front Radiol
Gao Z, Qian Y, Fan R, Yang Y, Wang Y, Xing L, Chen Y, Li Y, Sun H, Qiao Y.   +9 more
europepmc   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

A Novel Macro-Level Model in Evaluating Health and Safety Training Based on Virtual Reality. [PDF]

Int J Environ Res Public Health
Pireddu A, Giliberti C, Innocenti A, Simeoni C, Bonafede M.   +4 more
europepmc   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Evaluation of Generative Artificial Intelligence Implementation Impacts in Social and Health Care Language Translation: Mixed Methods Case Study. [PDF]

JMIR Form Res
Martikainen M, Smolander K, Sanmark J, Sanmark E.   +3 more
europepmc   +1 more source

Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids

FEBS Open Bio, EarlyView.
Sarcosine oxidase from Bacillus sp. (SoxB) recognizes l‐proline (l‐Pro), d‐proline (d‐Pro), and l‐thioproline (l‐Tpr) as minor substrates. In this study, we measured their absorption spectra, determined the crystal structures of their enzyme complexes, and performed site‐directed mutagenesis of key residues.
Yuqi Zhang, Yoshitaka Nakajima, Masae Kurobe, Tsutomu Nakamura, Tomoki Himiyama, Yoshiaki Nishiya   +5 more
wiley   +1 more source

PerAF-based resting-state fMRI classifier for minimal hepatic encephalopathy. [PDF]

Front Neurol
Zhang Y, Huang Z, Qin B, Tang S, Huang P, Tang X, Lin X, Liu Y, Deng X, Zhu F, Xing S, Liang Z.   +11 more
europepmc   +1 more source

Privacy-by-Design Approach to Generate Two Virtual Clinical Trials for Multiple Sclerosis and Release Them as Open Datasets: Evaluation Study.

J Med Internet Res
Demuth S, Rousseau O, Faddeenkov I, Paris J, De Sèze J, Baciotti B, Payet M, Guillaudeux M, Barreteau AF, Laplaud D, Edan G, Gourraud PA.   +11 more
europepmc   +1 more source

Dynamics of 4D supply chain system with fractal fractional derivatives insight of stability analysis and ANN prediction. [PDF]

Sci Rep
Zehra A, Farman M, Bonny T, Sambas A, Al Nassan W, Nisar KS, Voon BWN, Hafez M.   +7 more
europepmc   +1 more source