Results 41 to 50 of about 17,927 (312)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Fine grain software pipelining of non-vectorizable nested loops [PDF]
, 1991 This paper presents a new technique to parallelize nested loops at the statement level. It transforms sequential nested loops, either vectorizable or not, into parallel ones.
Kim, Ki-chang, Nicolau, Alexandru
core
On-Chip Transparent Wire Pipelining (invited paper) [PDF]
, 2004 Wire pipelining has been proposed as a viable mean to break the discrepancy between decreasing gate delays and increasing wire delays in deep-submicron technologies.
Casu, Mario Roberto, Macchiarulo, Luca
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Low Power Processor Architectures and Contemporary Techniques for Power Optimization – A Review [PDF]
, 2009 The technological evolution has increased the number of transistors for a given die area significantly and increased the switching speed from few MHz to GHz range.
Gujarathi, Hemal S +2 more
core +2 more sources
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Hardware/Software Solution for Low Power Evaluation of Tsunami Danger
Journal of Low Power Electronics and Applications, 2022 Carbon footprint reduction issues have been drawing more and more attention these days. Reducing the energy consumption is among the basic directions along this line. In the paper, a low-energy approach to tsunami danger evaluation is concerned.
Mikhail Lavrentiev +4 more
doaj +1 more source
An efficient global resource constrained technique for exploiting instruction level parallelism [PDF]
, 1992 A new Global Resource-constrained Percolation (GRiP) scheduling technique is presented for exploiting instruction level parallelism. Other techniques that have been proposed either have been prohibitively expensive in terms of computation or have limited
Nicolau, Alexandru, Novack, Steven
core
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source