Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu+18 more
wiley +1 more source
Ambient Artificial Intelligence Scribes: A Pilot Survey of Perspectives on the Utility and Documentation Burden in Palliative Medicine. [PDF]
Patterson J, Kovacs M, Lees C.
europepmc +1 more source
A SPEM BASED SOFTWARE PROCESS IMPROVEMENT META-MODEL
Rodrigo Santos de Espindola+1 more
openalex +1 more source
Systematic literature study for dimensional classification of success factors affecting process improvement in global software development: client–vendor perspective [PDF]
Arif Ali Khan+4 more
openalex +1 more source
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo+6 more
wiley +1 more source
A roadmap for a comparison framework for an adaptable software process improvement framework in small software companies [PDF]
Micheal Tuape, Yirsaw Ayalew
doaj +1 more source
Outreach simulation for system improvement: a novel advocacy and reporting process. [PDF]
St-Onge-St-Hilaire A+5 more
europepmc +1 more source
Barriers in the Implementation of Software Process Improvement Project in Saudi Arabia [PDF]
Fahad H. Alshammari
openalex +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak+8 more
wiley +1 more source