Results 131 to 140 of about 2,245,735 (312)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
IT & C Projects Duration Assessment Based on Audit and Software Reengineering [PDF]
This paper analyses the effect of applying the core elements of software engineering and reengineering, probabilistic simulations and system development auditing to software development projects.
Cosmin TOMOZEI +2 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A Novel Framework for RDF Schema Extraction in NoSQL Databases Using Sentence-BERT
IEEE AccessNoSQL databases, known for their flexibility and scalability, have become pivotal in handling diverse and unstructured data. However, their schema-less nature introduces significant challenges in metadata management, query optimization, and data ...
Saad Belefqih +3 more
doaj +1 more source
, 2012 Software organizations evolve and maintain software solutions with more than a single development project. The delta specifications and artefacts that result from each project make reuse difficult and challenge a company’s ability to innovate ...
Fricker, Samuel, Samuel A. Fricker
core +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Complex Software Project Development: Agile Methods Adoption
, 2011 Mishra, Alok/0000-0003-1275-2050; Kruchten, Philippe/0000-0003-1359-4867; Mishra, Deepti/0000-0001-5144-3811The Agile Software Development paradigm has become increasingly popular in the last few years, since it claims lower costs, better productivity ...
Mıshra, Deepti +3 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Insights into the prevalence of software project defects. [PDF]
ScientificWorldJournal, 2014 Alfonso-Cendón J +3 more
europepmc +1 more source
Emotional Awareness in Software Development: Evaluating Software Project Managers’ Perspectives
IEEE AccessDevelopers’ emotions significantly influence job satisfaction, motivation, productivity, and work quality throughout the software development lifecycle.
Leo Silva +2 more
doaj +1 more source