Results 141 to 150 of about 2,245,735 (312)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Software project management tools in global software development: a systematic mapping study. [PDF]

open access: yesSpringerplus, 2016
Chadli SY   +5 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Optimization of software project evaluation system

open access: yesSir Syed University Research Journal of Engineering and Technology, 2020
Starting from the problems of imperfect evaluation index system, non-standard evaluation method and single factor of performance evaluation model, this paper applies the unified grey clustering analysis algorithm to establish the index system of ...
Li ding .
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Combinatorial Testing in Software Projects

open access: yes, 2012
Software systems continuously grow in size and code complexity, the latter most evident through greater component interconnectedness. This leaves more space for bugs which introduce risks such as exposure to security threats. Combinatorial testing looks for interaction failures in order to improve the system security and effectiveness guarantees.
Brčić, Mario, Kalpić, Damir
openaire   +2 more sources

Project Portfolio Management Prototype Application Design [PDF]

open access: yes
The management of project portfolio in a company requires the use of specific software, especially when the number of projects is significant. This paper is based on the Methodology for the development of IT projects portfolio management applications ...
Paul POCATILU
core  

Home - About - Disclaimer - Privacy