Results 31 to 40 of about 627,961 (258)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
An Evaluation of Software Project Risk Management in South Africa
South African Journal of Industrial Engineering, 2013 Global research indicates that the success rate of software projects worldwide is currently very low, and has been low for the past few decades. The application of risk management has improved the success rate of software projects in the developed world.
De Wet, B., Visser, J. K.
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Open Source Approach to Project Management Tools [PDF]
Informatică economică, 2011 Managing large projects involving different groups of people and complex tasks can be challenging. The solution is to use Project management software, which allows a more efficient management of projects. However, famous project management systems can be
Romeo MARGEA, Camelia MARGEA
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Analysis of software solutions for project management support in project-oriented organisations [PDF]
Tehnika, 2014 The success of the project-oriented organization in a dynamic business environment is conditioned by use of software solutions for project management support. The paper presents a study of 238 software solutions for project management support.
Mitrović Zorica M. +2 more
doaj +1 more source
A Software Projects Crest and Trough in Pakistan: A Management Spectrum
Sukkur IBA Journal of Computing and Mathematical Sciences, 2023 Software industry has become as popular factor in the progress triumph of every country. Software project management techniques are significantly applicable in the development cycle of software projects.
Salwa iqbal +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Project risk management in Iranian software projects [PDF]
Journal of Engineering Management and Competitiveness, 2018 Many Software development organizations suffer chronic problems of cost overruns, schedule slips and projects that do not meet the originally specified functions in almost all software projects.
Afshari Ali Reza +2 more
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