Results 231 to 240 of about 11,494,549 (358)

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

MetaflowX: a scalable and resource-efficient workflow for multi-strategy metagenomic analysis. [PDF]

Nucleic Acids Res
Xia Y, Liang L, Wang X, Chen Z, Liu J, Yang Y, Xie H, Ding Z, Huang X, Long S, Wang Z, Xu X, Ding C, Chen Q, Feng Q.   +14 more
europepmc   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Software and pipelines for registration and analyses of rodent brain image data in reference atlas space. [PDF]

Front Neuroinform
Puchades MA, Yates SC, Csucs G, Carey H, Balkir A, Leergaard TB, Bjaalie JG.   +6 more
europepmc   +1 more source

Quality of Service (QoS) in Software Defined Networking (SDN): A survey

Journal of Network and Computer Applications, 2017
Murat Karakus, A. Durresi
semanticscholar   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

AXZ viewer: a web application to visualize unprocessed AFM-IR data. [PDF]

Bioinformatics
Duverger W, Ramer G, Louros N, Schymkowitz J, Rousseau F.   +4 more
europepmc   +1 more source

An industrial study on building consensus around software architectures and quality attributes

, 2004
Mikael Svahnberg
openalex   +2 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Mapping the "Ghost Fleet of Mallows Bay", Maryland with drone-based remote sensing. [PDF]

Sci Data
White EC, Seymour AC, Dale J, Newton E, Johnston DW.   +4 more
europepmc   +1 more source