Results 271 to 280 of about 5,112,197 (346)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Fixed Versus Patient-Specific Trigger Delay in High-Pitch Computed Tomography Angiography of the Aorta Prior to Transcatheter Aortic Valve Implantation: Assessment of Image Quality and Homogeneity of Vessel Enhancement. [PDF]

Invest Radiol
Sahin-Uzuner S, Zangeneh FA, De Almeida G, Krzystek O, Paslak M, Heimer J, Gutjahr R, Sartoretti T, Niemann T, Euler A.   +9 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

The role of social support in the association between quality of life and demoralization in patients with inflammatory bowel disease: a cross-sectional study. [PDF]

Front Psychol
Ji J, Gu H, Lei S, Shen P, Zheng J, Zhang Y.   +5 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

How perceived environmental quality influences physical activity in urban green spaces? A moderated mediation model. [PDF]

Front Public Health
Zhang P, Lin Y, Zhao B, Ma X, Luo Q, La C.   +5 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Impact of Plastic Surgery of Nail Folds Combined with Conservative Nail Plate Reconstruction on the Quality of Life in Patients with Ingrown Toenails: A DLQI-Based Study. [PDF]

J Clin Med
Trochanowski T, Dańczak-Pazdrowska A, Baum E.   +2 more
europepmc   +1 more source