Results 71 to 80 of about 3,221,112 (336)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Efficient Methods for Fast Shading

Advances in Electrical and Computer Engineering, 2008
On devices without battery consuming and specialized hardware for rendering, it is important to improve the speed and quality so that these methods are suitable for real-time rendering.
ROMANYUK, A., HAST, A., LYASHENKO, Y.
doaj   +1 more source

SCALABLE MULTI-PLATFORM DISTRIBUTION OF SPATIAL 3D CONTENTS [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2013
Virtual 3D city models provide powerful user interfaces for communication of 2D and 3D geoinformation. Providing high quality visualization of massive 3D geoinformation in a scalable, fast, and cost efficient manner is still a challenging task ...
J. Klimke, B. Hagedorn, J. Döllner
doaj   +1 more source

VolumeEVM: A new surface/volume integrated model [PDF]

, 2003
Volume visualization is a very active research area in the field of scien-tific visualization. The Extreme Vertices Model (EVM) has proven to be a complete intermediate model to visualize and manipulate volume data using a surface rendering approach ...
Ayala Vallespí, M. Dolors, Rodríguez Rojas, Jorge Ernesto   +1 more
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Performance Evaluation and Optimization of 3D Gaussian Splatting in Indoor Scene Generation and Rendering

ISPRS International Journal of Geo-Information
This study addresses the prevalent challenges of inefficiency and suboptimal quality in indoor 3D scene generation and rendering by proposing a parameter-tuning strategy for 3D Gaussian Splatting (3DGS).
Xinjian Fang, Yingdan Zhang, Hao Tan, Chao Liu, Xu Yang   +4 more
doaj   +1 more source

Detecting Automatic Software Plagiarism via Token Sequence Normalization

International Conference on Software Engineering
While software plagiarism detectors have been used for decades, the assumption that evading detection requires programming proficiency is challenged by the emergence of automated pla-giarism generators.
Timur Sağlam, Moritz Brödel, Larissa Schmid, Sebastian Hahner   +3 more
semanticscholar   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Dynamically reconfiguring software microbenchmarks: reducing execution time without sacrificing result quality

ESEC/SIGSOFT FSE, 2020
Executing software microbenchmarks, a form of small-scale performance tests predominantly used for libraries and frameworks, is a costly endeavor. Full benchmark suites take up to multiple hours or days to execute, rendering frequent checks, e.g., as ...
Christoph Laaber, Stefan Würsten, H. Gall, P. Leitner   +3 more
semanticscholar   +1 more source