Results 71 to 80 of about 469,775 (287)

Efficient Methods for Fast Shading [PDF]

, 2012
On devices without battery consuming and specialized hardware for rendering, it is important to improve the speed and quality so that these methods are suitable for real-time rendering.
Hast, Anders, Lyashenko, Y. L., Romanyuk, O. N., Ляшенко, Ю. Л., Ляшенко, Ю. Л., Романюк, А. Н., Романюк, О. Н., Хаст, Андерс, Хаста, Андерс   +8 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

High-Resolution Stereoscopic Visualization of Pediatric Echocardiography Data on Microsoft HoloLens 2

IEEE Access
Three-dimensional ultrasound offers volumetric images and detailed anatomical data for medical diagnosis and treatment planning. It is a key tool in the medical field to obtain a comprehensive view of the body.
Meruja Selvamanikkam, Michelle Noga, Nee Scze Khoo, Kumaradevan Punithakumar   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Interactive Visualization of the Largest Radioastronomy Cubes

, 2010
3D visualization is an important data analysis and knowledge discovery tool, however, interactive visualization of large 3D astronomical datasets poses a challenge for many existing data visualization packages.
A.H. Hassan, Barnes, Becciani, Beeson, C.J. Fluke, D.G. Barnes, Drebin, Goel, Graham, Hamada, Lacroute, Levoy, Li, Lombeyda, McClure-Griffiths, Oosterloo, Pence, Sabella, Samet, Schive, Thibault, Wayth   +21 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

CREATING 3D MODEL OF ARCHITECTURAL OBJECTS IN DIFFERENT SOFTWARE

Journal of Industrial Design and Engineering Graphics, 2019
Producing professional-quality 3D models is one of the main requirements in the work of architect. Behind photorealistic renderings lies the precise modeling of the building.
Nastasija Kocic
doaj   +4 more sources

Open-source software in medical imaging: development of OsiriX [PDF]

, 2018
Purpose Open source software (oss) development for medical imaging enables collaboration of individuals and groups to produce high-quality tools that meet user needs.
Ratib, Osman, Rosset, Antoine
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