Results 71 to 80 of about 6,242,010 (304)

Research on Knowledge Creation in Software Requirement Development

Journal of Software Engineering and Applications, 2010
After field survey and literature review, we found that software requirement development (SRD) is a knowledge creation process, and knowledge creation theory of Nonaka is appropriate for analyzing knowledge creating of SRD.
Jiangping Wan, Hui Zhang, Dan Wan, Deyi Huang   +3 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Ensemble Balanced Nested Dichotomy Fuzzy Models for Software Requirement Risk Prediction

IEEE Access
Modern software systems are becoming more intricate, making identification of risks in the software requirement phase— a fundamental aspect of the software development life cycle (SDLC)—complex.
Ganesh Kumar, Abdullahi Abubakar Imam, Shuib Basri, Ahmad Sobri Hashim, Abdul Ghani Haji Naim, Luiz Fernando Capretz, Abdullateef Oluwagbemiga Balogun, Hussaini Mamman   +7 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

APPLYING FUNCTION POINT METHOD TO MEASURE ENTREPRENEURSHIP SYSTEM SIZE AT UiTM

Malaysian Journal of Computing
Traditional estimation methods for assessing the size and scope of software systems often result in inaccuracies, leading to budget overruns and timeline delays.
Gazairi Ghazali, Mohd Hairy Mohamaddiah, Ahmad Sobri Abdul Haris, Syarifah Nurul Afzan Syed Mohammed   +3 more
doaj   +1 more source

Software Requirement Smells and Detection Techniques: A Systematic Literature Review

Cybernetics and Information Technologies
One of the major reasons for software project failure is poor requirements, so numerous requirement smells detection solutions are proposed. Critical appraisal of the proposed requirement fault detection methods is crucial for refining knowledge of ...
Alemneh Esubalew, Berhanu Fekerte
doaj   +1 more source

MLBRSA: Multi-Learning-Based Reptile Search Algorithm for Global Optimization and Software Requirement Prioritization Problems. [PDF]

Biomimetics (Basel), 2023
Kailasam JK, Nalliah R, Nallagoundanpalayam Muthusamy S, Manoharan P.   +3 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source