Results 41 to 50 of about 38,949 (255)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
MATEC Web of Conferences, 2016 It has been evidenced that one of the most common causes in the failure of software security is the lack of identification and specification of requirements for information security, it is an activity with an insufficient importance in the software ...
Adán Beltrán G. +5 more
doaj +1 more source
Nuclear Engineering and Technology, 2016 This paper presents a documentation and development method to facilitate the certification of scientific computing software used in the safety analysis of nuclear facilities.
W. Spencer Smith, Nirmitha Koothoor
doaj +1 more source
ReqSpecOnto: Investigating Explicit Software Requirements Specification
Innovative Computing Review, 2021 Specification of customer's need as software requirements in natural language create ambiguities in requirements and may also lead to failure of the software project. Generally, customers are unable to define their needs due to lack of domain understanding, technological constraints and knowledge gap between stakeholders and requirements analysts.
Usman Ahmed +2 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Documenting Software Requirements Specification: A Revisit
Computer and Information Science, 2010 Software Requirements Specification (SRS) is the key documentation, defining the functional and non-functional system requirements. By revisiting a number of in the literature much discussed key aspects related to SRS and extracting essential views from the author’s daily work experience, this papers stresses the importance of the SRS and examines the ...
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
QUALITY IMPROVING GRAPH MODEL AND METHOD FOR Software requirements specification
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 The graph model for software requirements specification is proposed. Besides, there are possible actions of improving the quality characteristics of software requirements described.
A. U. Chirkova, V. V. Bakhtizin
doaj
A reference measurement framework of software security product quality (SPQNFSR)
IET Information Security, 2021 Currently, the customer's demands have expressively amplified their expectations of getting software at a high‐quality level. However, the non‐functional requirements of the software products attention have been expanded in both the academic and the ...
Khalid T. Al‐Sarayreh +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source