Results 101 to 110 of about 143,683 (356)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
The Sizing and Optimization Language (SOL): A computer language to improve the user/optimizer interface [PDF]
The nonlinear mathematical programming method (formal optimization) has had many applications in engineering design. A figure illustrates the use of optimization techniques in the design process. The design process begins with the design problem, such as
Lucas, S. H., Scotti, S. J.
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Software Design Tool for Sizing PV Stand-Alone System and Hybrid PV-Diesel System with Iraq Climate
مجلة النهرين للعلوم الهندسية, 2019 This paper displays the improvement of Graphical User Interface programming for sizing principle segment in Stand-Alone PV system and PV- Diesel hybrid power system based on Iraq conditions.
Saja Majeed Hashim +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Aircraft Conceptual Structural Design Using the AMMIT Structural Analysis Tool [PDF]
Aircraft conceptual structural design is the process of developing and refining an idea for an aircraft into a feasible structural design. The process typically involves multiple evaluations of a single configuration and can require designers to examine ...
Horvath, Bryce L.
core +1 more source
Software Size Measurement: Bridging Research and Practice
IEEE SoftwareThis study investigates the limited adoption of functional size measurement methods in the software development industry. Using insights from firms experienced in size measurement, it aims to uncover industry expectations and facilitate the translation of theoretical methodologies into practical applications.
Tuna Hacaloğlu +3 more
openaire +2 more sources