Results 121 to 130 of about 143,683 (356)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Semi-Automated Nasal PAP Mask Sizing using Facial Photographs

, 2017
We present a semi-automated system for sizing nasal Positive Airway Pressure (PAP) masks based upon a neural network model that was trained with facial photographs of both PAP mask users and non-users.
de Chazal, Philip, Johnston, Benjamin, McEwan, Alistair   +2 more
core   +1 more source

Proposal of Support Application Software to Implement Hazard Identification of Machinery for Small and Medium-Sized Business Sites

, 2023
Toshiro Hoshi, Kazu IRISAWA, Tetsuya Kimura, Tsuyoshi Saito, Kyoko Hamajima, Hiroyasu IKEDA   +5 more
openalex   +2 more sources

Optimum Sizing and Placement of Wind Turbines in Distribution Networks Considering Correlation of Load Demand and Wind Power

Iranian Journal of Electrical and Electronic Engineering, 2021
Optimal placement and sizing of distributed renewable energy resources (DER) in distribution networks can remarkably influence voltage profile improvement, amending of congestions, increasing the reliability and emission reduction.
T. Agheb, I. Ahmadi, A. Zakariazadeh
doaj  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Impact of residential energy system sizing and control over heat pump’s system cost and reliability [PDF]

, 2011
Using a simulation-based approach, this work analyses the impact that different energy unit sizes and control methodologies will have over the capital and running costs of an air source heat pump (ASHP) system to be installed in a refurbished dwelling. A
Cooper, Catherine, Duncan, Douglas, Kelly, Nicolas, Lira, Lucas   +3 more
core  

Impact of femoral component flexion on implant sizing in unicompartmental knee arthroplasty: A three-dimensional computed tomography-based simulation study

Journal of Joint Surgery and Research
Purpose: Accurate femoral component sizing is essential for successful unicompartmental knee arthroplasty (UKA). This study aimed to investigate the effect of sagittal alignment on femoral component sizing using three-dimensional (3D) simulation and to ...
Kazu Matsumoto, Daichi Ishimaru, Kazuki Sohmiya, Nobuo Terabayashi   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Study of Estimation for Web Software Size [PDF]

, 2005
Jee-Hyun Kim, Hae-Young Yoo
openalex   +1 more source

Size matters? Or not: A/B testing with limited sample in automotive\n embedded software [PDF]

, 2021
Yuchu Liu, David Issa Mattos, Jan Bosch, Helena Holmström Olsson, Jonn Lantz   +4 more
openalex   +1 more source