Results 91 to 100 of about 6,415,956 (313)
A Nichesourcing Framework applied to Software Sustainability Requirements
Research Challenges in Information Science, 2019 Background] A software sustainability model is commonly defined in terms of social, economic, technical and environmental dimensions. A key challenge is its characterization regarding sustainability requirements and their dependencies since it depends on,
Nelly Condori-Fernández +3 more
semanticscholar +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
, 2018 This paper presents a new method of engaging older participants in the process of application and IT solutions development for older adults for emerging IT and tech startups.
Aula Anne +5 more
core +1 more source
Zero and low carbon buildings: A driver for change in working practices and the use of computer modelling and visualization [PDF]
, 2010 Buildings account for significant carbon dioxide emissions, both in construction and operation. Governments around the world are setting targets and legislating to reduce the carbon emissions related to the built environment.
Hetherington, Robina +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Understanding business strategies of networked value constellations using goal- and value modeling [PDF]
, 2006 In goal-oriented requirements engineering (GORE), one usually proceeds from a goal analysis to a requirements specification, usually of IT systems. In contrast, we consider the use of GORE for the design of IT-enabled value constellations, which are ...
Gordijn, Jaap +2 more
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Toward sustainable management: 2D modelling of a self-cleaning system to improve geometry in front of the flushing gate [PDF]
, 2018 This paper aims to show how numerical modelling based on 2D SWE can be used to analyze the cleaning effectiveness of flushing waves in storm tanks.
Choi, Gyewoon +4 more
core +4 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Improving Software Citation and Credit [PDF]
, 2015 The past year has seen movement on several fronts for improving software citation, including the Center for Open Science's Transparency and Openness Promotion (TOP) Guidelines, the Software Publishing Special Interest Group that was started at January's ...
Allen, Alice +10 more
core +1 more source