Results 121 to 130 of about 6,415,956 (313)

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Prompt-Based Learning for Factual Knowledge Infusion in Large Language Models

International Journal of Crowd Science
Large Language Models (LLMs) are increasingly employed in knowledge-intensive tasks but often struggle to effectively apply infused knowledge due to textual-structure mismatches between the infusion and reasoning phases. To address this issue, we propose
Ziheng Cheng, Yiming Cao
doaj   +1 more source

Visualising historical changes in air pollution with the Air Quality Stripes [PDF]

Geoscience Communication
This paper introduces the Air Quality Stripes, a data visualisation project which presents historical changes in outdoor particulate matter air pollution (PM2.5) concentrations across major cities worldwide.
K. J. Pringle, K. J. Pringle, R. Rigby, S. T. Turnock, S. T. Turnock, C. L. Reddington, M. Shayakhmetova, M. Illingworth, D. Barclay, D. Barclay, N. Chue Hong, N. Chue Hong, E. Hawkins, D. S. Hamilton, E. Brain, J. B. McQuaid   +15 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Editorial: Neuroscience, computing, performance, and benchmarks: Why it matters to neuroscience how fast we can compute

Frontiers in Neuroinformatics, 2023
James B. Aimone, Omar Awile, Markus Diesmann, Markus Diesmann, Markus Diesmann, James C. Knight, Thomas Nowotny, Felix Schürmann   +7 more
doaj   +1 more source

The Nebuchadnezzar Effect: Dreaming of Sustainable Software through Sustainable Software Architectures

, 2014
Sustainability is emerging as an area of growing interest in the field of software engineering. While there is no agreed definition of the concept it is increasingly being considered as a non-functional requirement; a desired quality of a software system.
Venters, Colin C., Griffiths, Michael K., Holmes, Violeta, Ward, Rupert R., Cooke, David J.   +4 more
openaire   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Using ICT to support public and private community memories: case studies and lessons learned [PDF]

, 2006
Information communication technologies (ICTs) enable the development of memories across a variety of communities. We identify a spectrum of deployment from private through to open public spaces.
Collins, T., Gaved, Mark, Heath, T., Mulholland, P., Zdrahal, Z.   +4 more
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Surveying the Environmental and Technical Dimensions of Sustainability in Software Development Companies

Applied Sciences, 2018
The growing concern over the state of degradation of the environment has led to a consideration of aspects relating to sustainability in software. Bearing this in mind, we have carried out a survey of practitioners, aiming to gather information about ...
José Alberto García-Berna, Juan Manuel Carrillo de Gea, Begoña Moros, José Luis Fernández-Alemán, Joaquín Nicolás, Ambrosio Toval   +5 more
doaj   +1 more source